Posttraumatic Stress Disorder in Patients with Heavy Alcohol Consumption and Alcoholic Hepatitis

Niharika Samala, Spencer G. Lourens, Vijay H. Shah, Patrick S. Kamath, Arun J. Sanyal, David Crabb, Qing Tang, Svetlana Radaeva, Suthat Liangpunsakul, Naga Chalasani

Research output: Contribution to journalArticle

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Abstract

Background: Lifetime prevalence of posttraumatic stress disorder (PTSD) in the general population is reported to be 6.8%. Individuals with alcohol dependence and substance abuse have high prevalence of PTSD. However, the prevalence of PTSD in heavy drinkers with alcoholic hepatitis (AH) is not known.The study's aim was to determine the prevalence of PTSD in heavy drinkers with and without AH. Methods: We screened for PTSD using the Primary Care-PTSD questionnaire among heavy drinkers with (n = 115) and without (n = 64) AH participating in a multicenter observational study in which participants were followed up to 12 months following their enrollment. Results: The prevalence of PTSD in heavy drinkers with AH was 34% and was not different from heavy drinking controls without liver disease (34%). In the entire group screened for PTSD, the presence of PTSD was associated with higher alcohol consumption as reported by average drinks per last 30 days and average grams of alcohol consumed per day (p = 0.047 for both tests), but not associated with relapse of heavy drinking or mortality. Similarly, patients with AH and PTSD did not have higher relapse rate or higher mortality compared to patients with AH but no PTSD. Conclusions: Compared to previously reported prevalence in general population, heavy drinking individuals with or without AH have significantly higher prevalence of PTSD. However, PTSD was not associated with higher relapse rate or higher mortality in this population.

Original languageEnglish (US)
JournalAlcoholism: Clinical and Experimental Research
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Alcoholic Hepatitis
Post-Traumatic Stress Disorders
Alcohol Drinking
Alcohols
Liver
Drinking
Recurrence
Alcoholism
Mortality
Population
Multicenter Studies
Substance-Related Disorders
Observational Studies

Keywords

  • Alcoholic Hepatitis
  • Alcoholic Liver Disease
  • Heavy Alcohol Drinkers
  • Posttraumatic Stress Disorder

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Posttraumatic Stress Disorder in Patients with Heavy Alcohol Consumption and Alcoholic Hepatitis. / Samala, Niharika; Lourens, Spencer G.; Shah, Vijay H.; Kamath, Patrick S.; Sanyal, Arun J.; Crabb, David; Tang, Qing; Radaeva, Svetlana; Liangpunsakul, Suthat; Chalasani, Naga.

In: Alcoholism: Clinical and Experimental Research, 01.01.2018.

Research output: Contribution to journalArticle

Samala, Niharika ; Lourens, Spencer G. ; Shah, Vijay H. ; Kamath, Patrick S. ; Sanyal, Arun J. ; Crabb, David ; Tang, Qing ; Radaeva, Svetlana ; Liangpunsakul, Suthat ; Chalasani, Naga. / Posttraumatic Stress Disorder in Patients with Heavy Alcohol Consumption and Alcoholic Hepatitis. In: Alcoholism: Clinical and Experimental Research. 2018.
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abstract = "Background: Lifetime prevalence of posttraumatic stress disorder (PTSD) in the general population is reported to be 6.8{\%}. Individuals with alcohol dependence and substance abuse have high prevalence of PTSD. However, the prevalence of PTSD in heavy drinkers with alcoholic hepatitis (AH) is not known.The study's aim was to determine the prevalence of PTSD in heavy drinkers with and without AH. Methods: We screened for PTSD using the Primary Care-PTSD questionnaire among heavy drinkers with (n = 115) and without (n = 64) AH participating in a multicenter observational study in which participants were followed up to 12 months following their enrollment. Results: The prevalence of PTSD in heavy drinkers with AH was 34{\%} and was not different from heavy drinking controls without liver disease (34{\%}). In the entire group screened for PTSD, the presence of PTSD was associated with higher alcohol consumption as reported by average drinks per last 30 days and average grams of alcohol consumed per day (p = 0.047 for both tests), but not associated with relapse of heavy drinking or mortality. Similarly, patients with AH and PTSD did not have higher relapse rate or higher mortality compared to patients with AH but no PTSD. Conclusions: Compared to previously reported prevalence in general population, heavy drinking individuals with or without AH have significantly higher prevalence of PTSD. However, PTSD was not associated with higher relapse rate or higher mortality in this population.",
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author = "Niharika Samala and Lourens, {Spencer G.} and Shah, {Vijay H.} and Kamath, {Patrick S.} and Sanyal, {Arun J.} and David Crabb and Qing Tang and Svetlana Radaeva and Suthat Liangpunsakul and Naga Chalasani",
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