Potassium currents in CA1 neurons of rat hippocampus increase shortly after transient cerebral ischemia

Xian Xuan Chi, Zao C. Xu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Total potassium current in CA1 pyramidal neurons was studied using whole-cell voltage-clamp recording technique in hippocampal slices prepared before and at 6-8 h after transient forebrain ischemia. The total potassium current significantly increased from a control value of 2.17±0.17 to 2.96±0.31 nA (measured at +70 mV, P<0.05) after ischemia. The slope factor V(c) of activation curve significantly decreased and the half-inactivation voltage V(h) shifted to more depolarized potentials after ischemia. These results indicate that the increase of potassium current might be responsible for the decreased excitability in CA1 neurons after severe ischemia and may be involved in postischemic cell death in hippocampus. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalNeuroscience Letters
Volume281
Issue number1
DOIs
StatePublished - Mar 3 2000

Fingerprint

Transient Ischemic Attack
Hippocampus
Potassium
Ischemia
Neurons
Pyramidal Cells
Patch-Clamp Techniques
Prosencephalon
Cell Death

Keywords

  • Cell death
  • Cerebral ischemia
  • Excitability
  • Potassium current

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Potassium currents in CA1 neurons of rat hippocampus increase shortly after transient cerebral ischemia. / Xuan Chi, Xian; Xu, Zao C.

In: Neuroscience Letters, Vol. 281, No. 1, 03.03.2000, p. 5-8.

Research output: Contribution to journalArticle

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