Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B

Meng Taing, Yen Fang Keng, Kui Shen, Li Wu, David S. Lawrence, Zhong Yin Zhang

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Several protein tyrosine phosphatases (PTPases) have been implicated as regulatory agents in the insulin-stimulated signal transduction pathway, including PTP1B, PTPα, and LAR. Furthermore, since all three enzymes are suggested to serve as negative regulators of insulin signaling, one or more may play a pivotal role in the pathogenesis of insulin resistance. We report herein the acquisition of highly selective PTP1B-targeted inhibitors. We recently demonstrated that PTP1B contains two proximal aromatic phosphate binding sites [Puius, Y. A., Zhao, Y., Sullivan, M., Lawrence, D. S., Almo S. C., and Zhang, Z. Y. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 13420-5], and we have now employed this structural feature to design and synthesize an array of bis(aryldifluorophosphonates). Not only do the lead compounds serve as potent inhibitors of PTP1B but, in addition, several exhibit selectivities for PTP1B versus PTPα, LAR, and VHR that are greater than 2 orders in magnitude.

Original languageEnglish (US)
Pages (from-to)3793-3803
Number of pages11
JournalBiochemistry
Volume38
Issue number12
DOIs
StatePublished - Mar 23 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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