Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates

Jiyong Lee, D. Gomika Udugamasooriya, Hyun Suk Lim, Thomas Kodadek

Research output: Contribution to journalArticle

55 Scopus citations


Advances in high-throughput screening now enable the rapid discovery of bioactive small molecules, but these primary hits almost always exhibit modest potency. We report a strategy for the transformation of these hits into much more potent inhibitors without compound optimization. Appending a derivative of Ru(II)(tris-bipyridyl) 2+, an efficient photosensitizer of singlet oxygen production, to synthetic protein-binding compounds results in highly potent and specific target protein inactivation upon irradiation with visible light.

Original languageEnglish (US)
Pages (from-to)258-260
Number of pages3
JournalNature chemical biology
Issue number4
StatePublished - Apr 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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