Potential Approaches for Myocardial Regeneration

MARK H. SOONPAA, ADIL I. DAUD, GOU YOUNG KOH, MICHAEL G. KLUG, KYUNG KEUN KIM, HE WANG, LOREN J. FIELD

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Cardiomyocytes in the adult mammal retain little or none of their developmental capacity for hyperplastic growth. As a consequence of this differentiated, nonproliferative phenotype, cardiomyocyte loss due to injury or disease is irreversible. Therapeutic intervention in end-stage diseased hearts is currently limited to cardiac transplantation. An increase in cardiomyocyte number in diseased hearts could improve function. Augmentation of the cardiomyocyte population may be achievable by the expression of regulatory proteins in the myocardium, or by intracardiac grafting of exogenous cardiomyocytes.

Original languageEnglish (US)
Pages (from-to)446-454
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume752
Issue number1
DOIs
StatePublished - Mar 1995

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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