Potentiation of antidepressant medications by phase advance of the sleep-wake cycle

D. A. Sack, J. Nurnberger, N. E. Rosenthal, E. Ashburn, T. A. Wehr

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Four patients with major depression who were unresponsive to antidepressant medications rapidly improved and remained euthymic after an advance of the sleep-wake cycle. Phase advance of the sleep-wake cycle and antidepressant treatment may have complementary effects on the circadian system. The authors suggest that the combination may be useful in treating drug nonresponders and in hastening response to antidepressant drugs.

Original languageEnglish (US)
Pages (from-to)606-608
Number of pages3
JournalAmerican Journal of Psychiatry
Volume142
Issue number5
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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