POU-domain sequences from the flatworm Dugesia tigrina

Gary W. Stuart, Zhu Zhu, Karuna Sampath, Michael W. King

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Redundant primers matching well-conserved sequences within vertebrate and invertebrate POU genes were used in the PCR (polymerase chain reaction) to detect three different POU-domain-containing genes within the genome of the flatworm, Dugesia tigrina. Two of these genes appear to be close homologues of class-III POU genes previously identified in Dugesia japonica, while the third represents a new class-III POU gene. Nucleotide sequences encoding highly related POU domains within the two species of planaria exhibited a surprisingly poor degree of shared identity. Since only class-III POU genes have been observed to date in flatworms, these genes may represent ancestral versions of the multiple classes of PO U genes that exist in vertebrates, and may play important roles in the development of metazoan nervous tissue.

Original languageEnglish (US)
Pages (from-to)299-300
Number of pages2
JournalGene
Volume161
Issue number2
DOIs
StatePublished - Aug 19 1995

Keywords

  • DNA-binding protein
  • molecular evolution
  • planaria
  • transcription factor

ASJC Scopus subject areas

  • Genetics

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