Power calculation in stepped-wedge cluster randomized trial with reduced intervention sustainability effect

Jing Li, Ying Zhang, Laura J. Myers, Dawn M. Bravata

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The stepped-wedge design for pragmatic clinical trials has received increased attention in health service-related research seeking to evaluate the effect of interventions. Compared with the parallel design, the stepped-wedge design is preferred when there is prior knowledge supporting the effectiveness and harmlessness of the intervention, and/or when practical or financial constraints exist such that the intervention can only be implemented sequentially on a fraction of clusters. In some health service studies, the study period may consist of two parts: an active implementation followed by a sustainability phase, where the intervention effect is possibly reduced. There is a gap in current literature of the stepped-wedge design for cluster randomization trials for dealing with this specific scenario. We aim to provide an analytical formula for power analysis under this situation to aid the stepped-wedge design of an ongoing PREVENT trial.

Original languageEnglish (US)
Pages (from-to)663-674
Number of pages12
JournalJournal of biopharmaceutical statistics
Volume29
Issue number4
DOIs
StatePublished - Jul 4 2019

Keywords

  • Stepped-wedge design
  • cluster randomized trials
  • power analysis
  • pragmatic clinical trials

ASJC Scopus subject areas

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Power calculation in stepped-wedge cluster randomized trial with reduced intervention sustainability effect'. Together they form a unique fingerprint.

  • Cite this