Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure

Gianfranco Piccirillo, Masahiro Ogawa, Juan Song, Voon J. Chong, Boyoung Joung, Seongwook Han, Damiano Magrì, Lan Chen, Shien-Fong Lin, Peng-Sheng Chen

Research output: Contribution to journalArticle

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Abstract

Background: Heart rate variability (HRV), calculated in the frequency or time domain, decreases in congestive heart failure (CHF). In HRV power spectral analysis, the low-frequency (LF) component diminishes in patients with CHF and the decrease is related to an increased risk of sudden death. Objective: Our aim was to clarify the nature of HRV power spectral analysis in normal and CHF dogs. Methods: Using an implanted radiotransmitter, we directly studied integrated left stellate ganglion nerve activity (iSGNA), integrated vagal nerve activity (iVNA), and electrocardiographic tracings before and after pacing-induced CHF in 6 ambulatory dogs. In a short-term power spectral analysis of HRV, we measured power spectral density during high, medium, and low sympathetic and vagal nerve activity. We analyzed 38 data segments characterized by the same autonomic nerve activity patterns at baseline and after pacing-induced CHF. Results: As compared with baseline, the spectral variables during CHF showed decreased total power (P = .002), LF power (P < .0001), and the LF/high frequency (HF) ratio (P = .005) and increased iVNA and iSGNA (P < .0001 for both). Only at baseline, iSGNA correlated positively with LF power (P < .05, r = 0.314). Under the same condition iVNA correlated positively with the HF component expressed as normalized units (P < .05, r = 0.394) and negatively with the LF component expressed both as absolute power (P < .05, r = -0.464) and normalized units (P < .05, r = -0.425). Conclusion: The spectral variables (LF power and the LF/HF ratio) and direct variables measuring sympathetic nerve activity (iSGNA) correlate at baseline but not during CHF. At baseline, the vagal activity (iVNA) is associated with an increase in HFnu and a decrease in LFnu. These data indicate that the reduction in LF power and LF/HF ratio observed in heart failure dogs are likely to reflect a diminished sinus node responsiveness to autonomic modulation or an abnormal baroreflex function rather than an increased sympathetic activity.

Original languageEnglish
Pages (from-to)546-552
Number of pages7
JournalHeart Rhythm
Volume6
Issue number4
DOIs
StatePublished - Apr 2009

Fingerprint

Autonomic Nervous System
Tachycardia
Heart Failure
Heart Rate
Dogs
Stellate Ganglion
Autonomic Pathways
Sinoatrial Node
Baroreflex
Sudden Death

Keywords

  • Autonomic nervous system
  • Congestive heart failure
  • Heart rate variability
  • Power spectral analysis
  • Sudden death
  • Sympathetic nerve activity
  • Vagal nerve activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure. / Piccirillo, Gianfranco; Ogawa, Masahiro; Song, Juan; Chong, Voon J.; Joung, Boyoung; Han, Seongwook; Magrì, Damiano; Chen, Lan; Lin, Shien-Fong; Chen, Peng-Sheng.

In: Heart Rhythm, Vol. 6, No. 4, 04.2009, p. 546-552.

Research output: Contribution to journalArticle

Piccirillo, Gianfranco ; Ogawa, Masahiro ; Song, Juan ; Chong, Voon J. ; Joung, Boyoung ; Han, Seongwook ; Magrì, Damiano ; Chen, Lan ; Lin, Shien-Fong ; Chen, Peng-Sheng. / Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure. In: Heart Rhythm. 2009 ; Vol. 6, No. 4. pp. 546-552.
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author = "Gianfranco Piccirillo and Masahiro Ogawa and Juan Song and Chong, {Voon J.} and Boyoung Joung and Seongwook Han and Damiano Magr{\`i} and Lan Chen and Shien-Fong Lin and Peng-Sheng Chen",
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T1 - Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure

AU - Piccirillo, Gianfranco

AU - Ogawa, Masahiro

AU - Song, Juan

AU - Chong, Voon J.

AU - Joung, Boyoung

AU - Han, Seongwook

AU - Magrì, Damiano

AU - Chen, Lan

AU - Lin, Shien-Fong

AU - Chen, Peng-Sheng

PY - 2009/4

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N2 - Background: Heart rate variability (HRV), calculated in the frequency or time domain, decreases in congestive heart failure (CHF). In HRV power spectral analysis, the low-frequency (LF) component diminishes in patients with CHF and the decrease is related to an increased risk of sudden death. Objective: Our aim was to clarify the nature of HRV power spectral analysis in normal and CHF dogs. Methods: Using an implanted radiotransmitter, we directly studied integrated left stellate ganglion nerve activity (iSGNA), integrated vagal nerve activity (iVNA), and electrocardiographic tracings before and after pacing-induced CHF in 6 ambulatory dogs. In a short-term power spectral analysis of HRV, we measured power spectral density during high, medium, and low sympathetic and vagal nerve activity. We analyzed 38 data segments characterized by the same autonomic nerve activity patterns at baseline and after pacing-induced CHF. Results: As compared with baseline, the spectral variables during CHF showed decreased total power (P = .002), LF power (P < .0001), and the LF/high frequency (HF) ratio (P = .005) and increased iVNA and iSGNA (P < .0001 for both). Only at baseline, iSGNA correlated positively with LF power (P < .05, r = 0.314). Under the same condition iVNA correlated positively with the HF component expressed as normalized units (P < .05, r = 0.394) and negatively with the LF component expressed both as absolute power (P < .05, r = -0.464) and normalized units (P < .05, r = -0.425). Conclusion: The spectral variables (LF power and the LF/HF ratio) and direct variables measuring sympathetic nerve activity (iSGNA) correlate at baseline but not during CHF. At baseline, the vagal activity (iVNA) is associated with an increase in HFnu and a decrease in LFnu. These data indicate that the reduction in LF power and LF/HF ratio observed in heart failure dogs are likely to reflect a diminished sinus node responsiveness to autonomic modulation or an abnormal baroreflex function rather than an increased sympathetic activity.

AB - Background: Heart rate variability (HRV), calculated in the frequency or time domain, decreases in congestive heart failure (CHF). In HRV power spectral analysis, the low-frequency (LF) component diminishes in patients with CHF and the decrease is related to an increased risk of sudden death. Objective: Our aim was to clarify the nature of HRV power spectral analysis in normal and CHF dogs. Methods: Using an implanted radiotransmitter, we directly studied integrated left stellate ganglion nerve activity (iSGNA), integrated vagal nerve activity (iVNA), and electrocardiographic tracings before and after pacing-induced CHF in 6 ambulatory dogs. In a short-term power spectral analysis of HRV, we measured power spectral density during high, medium, and low sympathetic and vagal nerve activity. We analyzed 38 data segments characterized by the same autonomic nerve activity patterns at baseline and after pacing-induced CHF. Results: As compared with baseline, the spectral variables during CHF showed decreased total power (P = .002), LF power (P < .0001), and the LF/high frequency (HF) ratio (P = .005) and increased iVNA and iSGNA (P < .0001 for both). Only at baseline, iSGNA correlated positively with LF power (P < .05, r = 0.314). Under the same condition iVNA correlated positively with the HF component expressed as normalized units (P < .05, r = 0.394) and negatively with the LF component expressed both as absolute power (P < .05, r = -0.464) and normalized units (P < .05, r = -0.425). Conclusion: The spectral variables (LF power and the LF/HF ratio) and direct variables measuring sympathetic nerve activity (iSGNA) correlate at baseline but not during CHF. At baseline, the vagal activity (iVNA) is associated with an increase in HFnu and a decrease in LFnu. These data indicate that the reduction in LF power and LF/HF ratio observed in heart failure dogs are likely to reflect a diminished sinus node responsiveness to autonomic modulation or an abnormal baroreflex function rather than an increased sympathetic activity.

KW - Autonomic nervous system

KW - Congestive heart failure

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KW - Power spectral analysis

KW - Sudden death

KW - Sympathetic nerve activity

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