Practical methods for competing risks data: A review

Giorgos Bakoyannis, Giota Touloumi

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Competing risks data arise naturally in medical research, when subjects under study are at risk of more than one mutually exclusive event such as death from different causes. The competing risks framework also includes settings where different possible events are not mutually exclusive but the interest lies on the first occurring event. For example, in HIV studies where seropositive subjects are receiving highly active antiretroviral therapy (HAART), treatment interruption and switching to a new HAART regimen act as competing risks for the first major change in HAART. This article introduces competing risks data and critically reviews the widely used statistical methods for estimation and modelling of the basic (estimable) quantities of interest. We discuss the increasingly popular Fine and Gray model for subdistribution hazard of interest, which can be readily fitted using standard software under the assumption of administrative censoring. We present a simulation study, which explores the robustness of inference for the subdistribution hazard to the assumption of administrative censoring. This shows a range of scenarios within which the strictly incorrect assumption of administrative censoring has a relatively small effect on parameter estimates and confidence interval coverage. The methods are illustrated using data from HIV-1 seropositive patients from the collaborative multicentre study CASCADE (Concerted Action on SeroConversion to AIDS and Death in Europe).

Original languageEnglish (US)
Pages (from-to)257-272
Number of pages16
JournalStatistical Methods in Medical Research
Volume21
Issue number3
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Fingerprint

Competing Risks
Censoring
Therapy
Highly Active Antiretroviral Therapy
Mutually exclusive
Hazard
Grey Model
HIV Seropositivity
Statistical method
Confidence interval
Coverage
Proportional Hazards Models
Strictly
Multicenter Studies
Simulation Study
HIV-1
Biomedical Research
Cause of Death
Robustness
Software

Keywords

  • cause-specific hazard
  • competing risks
  • cumulative incidence
  • Fine and Gray model

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability
  • Health Information Management

Cite this

Practical methods for competing risks data : A review. / Bakoyannis, Giorgos; Touloumi, Giota.

In: Statistical Methods in Medical Research, Vol. 21, No. 3, 01.06.2012, p. 257-272.

Research output: Contribution to journalArticle

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