Practice databases and their uses in clinical research

William M. Tierney, Clement J. McDonald

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

A few large clinical information databases have been established within larger medical information systems. Although they are smaller than claims databases, these clinical databases offer several advantages: accurate and timely data, rich clinical detail, and continuous parameters (for example, vital signs and laboratory results). However, the nature of the data vary considerably, which affects the kinds of secondary analyses that can be performed. These databases have been used to investigate clinical epidemiology, risk assessment, post-marketing surveillance of drugs, practice variation, resource use, quality assurance, and decision analysis. In addition, practice databases can be used to identify subjects for prospective studies. Further methodologic developments are necessary to deal with the prevalent problems of missing data and various forms of bias if such databases are to grow and contribute valuable clinical information.

Original languageEnglish (US)
Pages (from-to)541-557
Number of pages17
JournalStatistics in Medicine
Volume10
Issue number4
DOIs
StatePublished - Apr 1991

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

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