Precision of biomarkers to define chronic inflammation in CKD

Robert Laclair, Kalisha O'Neal, Susan Ofner, Marcelo J. Sosa, Carlos A. Labarrere, Sharon M. Moe

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background/Aims: Several inflammatory biomarkers have been found to be associated with cardiovascular disease or all-cause mortality in dialysis patients, but their usefulness in clinical practice or as surrogate endpoints is not certain. The purpose of the present study was to determine the intrapatient variation of C-reactive protein, IL-6, fetuin-A and albumin in a population of dialysis patients. Methods: Apparently healthy dialysis patients with either a tunneled dialysis catheter or fistula had monthly assessments of these biomarkers for a total of four determinations, and the intraclass correlation coefficients were calculated as measures of intersubject variance. Results: Our results showed large within-subject variation relative to the total variation in the measurements (31-46%). Having a tunneled catheter as opposed to a fistula was not significantly associated with mean levels, suggesting that chronic subclinical catheter infection does not explain the variation seen in the biomarkers. In contrast, there was a rapid change in these biomarkers with a clinically apparent acute infection. Conclusion: These results suggest that these biomarkers have limitations for use as surrogate endpoints in clinical trials due to wide fluctuations, even in apparently clinically healthy individuals.

Original languageEnglish (US)
Pages (from-to)808-812
Number of pages5
JournalAmerican journal of nephrology
Volume28
Issue number5
DOIs
StatePublished - Sep 1 2008

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Keywords

  • Biomarkers, precision
  • Chronic inflammation
  • Chronic kidney disease
  • CKD stage 5D
  • Inflammatory biomarkers, intrapatient variance
  • Tunneled dialysis catheter

ASJC Scopus subject areas

  • Nephrology

Cite this

Laclair, R., O'Neal, K., Ofner, S., Sosa, M. J., Labarrere, C. A., & Moe, S. M. (2008). Precision of biomarkers to define chronic inflammation in CKD. American journal of nephrology, 28(5), 808-812. https://doi.org/10.1159/000135692