Preclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don’t) Aspects of Human Bone

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Preclinical studies play an indispensable role in exploring the biological regulation of the musculoskeletal system. They are required in all drug development pipelines where both small and large animal models are needed to understand efficacy and side effects. This brief review highlights 4 aspects of human bone, longitudinal bone growth, intracortical remodeling, collagen/mineral interface, and age-related changes, and discusses how various animal models recapitulate (or don’t) these aspects of human skeletal physiology.

Original languageEnglish (US)
Pages (from-to)851-854
Number of pages4
JournalToxicologic Pathology
Volume45
Issue number7
DOIs
StatePublished - Oct 1 2017

Keywords

  • aging
  • animal model
  • longitudinal growth
  • mineral/collagen
  • remodeling

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

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