Preconditioning: evolution of basic mechanisms to potential therapeutic strategies.

Ben M. Tsai, Meijing Wang, Keith L. March, Mark W. Turrentine, John W. Brown, Daniel R. Meldrum

Research output: Contribution to journalReview article

55 Scopus citations


Preconditioning describes the phenomenon by which a traumatic or stressful stimulus confers protection against subsequent injury. Originally recognized in dog heart subjected to ischemic challenges, preconditioning has been demonstrated in multiple species, can be induced by various stimuli, and is applicable in different organ systems. Tremendous progress has been made elucidating the signal transduction cascade of preconditioning. Preconditioning represents a potent tissue-protective condition, and mechanistic understanding may allow safe clinical application. This review recalls the history of preconditioning and how it relates to the history of the investigation of endogenous adaptation; summarizes the current mechanistic understanding of acute preconditioning; outlines the signal transduction cascade leading to the development of delayed preconditioning; discusses preconditioning in noncardiac tissue; and explores the potential of using preconditioning clinically.

Original languageEnglish (US)
Pages (from-to)195-209
Number of pages15
JournalShock (Augusta, Ga.)
Issue number3
StatePublished - Mar 2004

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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