Preconditioning

Gender effects

Jeffrey M. Pitcher, Meijing Wang, Ben M. Tsai, Ajay Kher, Mark Turrentine, John Brown, Daniel R. Meldrum

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Preconditioning is injury induced protection from subsequent injury. During preconditioning protective cellular responses to injury are up regulated resulting in acute and delayed defense against further damage. Several studies indicate that females experience a protective advantage after acute insult compared to males. Despite evidence of gender differences in acute injury, relatively few studies have evaluated whether there are sex differences in preconditioning. Variations in patients' pre-morbid preconditioning status may explain outcome variations that are not apparent in small animal studies. This review discusses the differences in response to acute injury experienced by males and females, the basic mechanisms of preconditioning, and the sex differences in the mechanisms of preconditioning.

Original languageEnglish
Pages (from-to)202-220
Number of pages19
JournalJournal of Surgical Research
Volume129
Issue number2
DOIs
StatePublished - Dec 2005

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Wounds and Injuries
Sex Characteristics

Keywords

  • Acute injury
  • Inflammation
  • Sex
  • Tolerance

ASJC Scopus subject areas

  • Surgery

Cite this

Preconditioning : Gender effects. / Pitcher, Jeffrey M.; Wang, Meijing; Tsai, Ben M.; Kher, Ajay; Turrentine, Mark; Brown, John; Meldrum, Daniel R.

In: Journal of Surgical Research, Vol. 129, No. 2, 12.2005, p. 202-220.

Research output: Contribution to journalArticle

Pitcher, Jeffrey M. ; Wang, Meijing ; Tsai, Ben M. ; Kher, Ajay ; Turrentine, Mark ; Brown, John ; Meldrum, Daniel R. / Preconditioning : Gender effects. In: Journal of Surgical Research. 2005 ; Vol. 129, No. 2. pp. 202-220.
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