Prediction of boundaries between intrinsically ordered and disordered protein regions.

Predrag Radivojac, Zoran Obradović, Celeste J. Brown, A. Dunker

Research output: Chapter in Book/Report/Conference proceedingChapter

52 Citations (Scopus)

Abstract

Using proteins with both disordered and ordered regions collected through literature searches and database scanning, we assembled a set of 24-residue long segments centered on their order/disorder boundaries as well as a larger set of non-boundary segments consisting of either order or disorder. We analyzed position-specific amino acid compositions around the order/disorder boundaries and found more than thirty significant (p <0.05) compositional differences between boundary and non-boundary data. From this analysis, we constructed several logistic regression predictors of order/disorder boundaries using slightly different data modeling approaches. Exact boundary prediction accuracies were estimated to be in the range from 74% to 80% for the different predictors.

Original languageEnglish (US)
Title of host publicationPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Pages216-227
Number of pages12
StatePublished - 2003
Externally publishedYes

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Intrinsically Disordered Proteins
Logistic Models
Databases
Amino Acids
Proteins

Cite this

Radivojac, P., Obradović, Z., Brown, C. J., & Dunker, A. (2003). Prediction of boundaries between intrinsically ordered and disordered protein regions. In Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing (pp. 216-227)

Prediction of boundaries between intrinsically ordered and disordered protein regions. / Radivojac, Predrag; Obradović, Zoran; Brown, Celeste J.; Dunker, A.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2003. p. 216-227.

Research output: Chapter in Book/Report/Conference proceedingChapter

Radivojac, P, Obradović, Z, Brown, CJ & Dunker, A 2003, Prediction of boundaries between intrinsically ordered and disordered protein regions. in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. pp. 216-227.
Radivojac P, Obradović Z, Brown CJ, Dunker A. Prediction of boundaries between intrinsically ordered and disordered protein regions. In Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2003. p. 216-227
Radivojac, Predrag ; Obradović, Zoran ; Brown, Celeste J. ; Dunker, A. / Prediction of boundaries between intrinsically ordered and disordered protein regions. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2003. pp. 216-227
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