Prediction of kidney mercury content by isotope techniques

J. B. Hursh, T. W. Clarkson, T. V. Nowak, R. C. Pabico, B. A. McKenna, E. Miles, F. R. Gibb

Research output: Contribution to journalArticle

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Abstract

A 61-year-old female patient accidentally aspirated liquid mercury during a medically ordered diagnostic procedure. To develop animal-based guidelines, liquid mercury was introduced into the lungs of four dogs. Based on the study of these animals, a method of predicting the kidney inorganic mercury burden was developed using radioactive isotope dilution techniques. It was further demonstrated in dogs that oral administration of dimercaptopropane sulfonate (DMPS) increased mercury excretion and reduced the kidney burden. A rat experiment was performed permitting a statistical evaluation of the assumptions basic to the use of the method. The method was applied to the patient with the result that the kidney inorganic mercury burden was predicted to be 28.1 mg, 8 months after the accident. Treatment with DMPS increased urinary excretion and the post-treatment kidney burden was estimated at 19.6 mm Hg. Inasmuch as the radioactive dose to the subject may be kept at a negligible level and because sensitive methods exist for measurement of radioactive and stable mercury concentrations, the technique may be applicable in special cases to the estimation of kidney inorganic mercury burdens incurred by industrial exposure.

Original languageEnglish (US)
Pages (from-to)898-907
Number of pages10
JournalKidney international
Volume27
Issue number6
DOIs
StatePublished - Jan 1 1985

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Mercury Isotopes
Mercury
Kidney
Dogs
Indicator Dilution Techniques
Radioisotopes
Accidents
Oral Administration
Guidelines

ASJC Scopus subject areas

  • Nephrology

Cite this

Hursh, J. B., Clarkson, T. W., Nowak, T. V., Pabico, R. C., McKenna, B. A., Miles, E., & Gibb, F. R. (1985). Prediction of kidney mercury content by isotope techniques. Kidney international, 27(6), 898-907. https://doi.org/10.1038/ki.1985.98

Prediction of kidney mercury content by isotope techniques. / Hursh, J. B.; Clarkson, T. W.; Nowak, T. V.; Pabico, R. C.; McKenna, B. A.; Miles, E.; Gibb, F. R.

In: Kidney international, Vol. 27, No. 6, 01.01.1985, p. 898-907.

Research output: Contribution to journalArticle

Hursh, JB, Clarkson, TW, Nowak, TV, Pabico, RC, McKenna, BA, Miles, E & Gibb, FR 1985, 'Prediction of kidney mercury content by isotope techniques', Kidney international, vol. 27, no. 6, pp. 898-907. https://doi.org/10.1038/ki.1985.98
Hursh JB, Clarkson TW, Nowak TV, Pabico RC, McKenna BA, Miles E et al. Prediction of kidney mercury content by isotope techniques. Kidney international. 1985 Jan 1;27(6):898-907. https://doi.org/10.1038/ki.1985.98
Hursh, J. B. ; Clarkson, T. W. ; Nowak, T. V. ; Pabico, R. C. ; McKenna, B. A. ; Miles, E. ; Gibb, F. R. / Prediction of kidney mercury content by isotope techniques. In: Kidney international. 1985 ; Vol. 27, No. 6. pp. 898-907.
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