Prediction of local recurrence of ductal carcinoma in situ of the breast using five histological classifications

A comparative study with long follow-up

Sunil Badve, Roger P. A'Hern, Ann M. Ward, Rosemary R. Millis, Sarah E. Pinder, Ian O. Ellis, Barry A. Gusterson, John P. Sloane

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The increased detection of ductal carcinoma in situ (DCIS) by mammographic screening and the more widespread use of breast-conserving surgery have led to a search for histological features associated with the risk of recurrence. In a case control study of 141 patients with long follow- up, we compared the ability of five morphological classifications to predict recurrence after local excision. A significant correlation was not found between recurrence and growth pattern when a traditional classification based on architecture was used nor with necrosis when a scheme based principally on this feature was employed. A correlation was, however, found between recurrence and differentiation as defined by nuclear features and cell polarization in a classification recently formulated by the European Pathologists Working Group (EPWG), but this failed to reach statistical significance at the 5% level. A stronger and statistically significant correlation was found between nuclear grade as defined by the EPWG and recurrence when cell polarization was disregarded, using the classification currently employed by the UK National Health Service and European Commission- funded Breast Screening Programmes. This was attributable to a small number of recurring cases being downgraded as a consequence of exhibiting polarized cells. A significant correlation between histology and recurrence was also observed using the Van Nuys classification, which is based on nuclear grade and necrosis. Whether the tumor recurred as in situ or invasive carcinoma was unrelated to histological classification, as was the time course over which it occurred. These findings strongly support the use of nuclear grade to identify cases of DCIS at high risk of recurrence after local excision, but further work is necessary to determine whether nuclear grade or necrosis is more appropriate to subdivide the non-high-grade cases.

Original languageEnglish (US)
Pages (from-to)915-923
Number of pages9
JournalHuman Pathology
Volume29
Issue number9
DOIs
StatePublished - 1998
Externally publishedYes

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Carcinoma, Intraductal, Noninfiltrating
Breast
Recurrence
Necrosis
Segmental Mastectomy
National Health Programs
Case-Control Studies
Histology
Carcinoma
Growth

Keywords

  • Breast
  • Classification
  • Ductal carcinoma in situ
  • Recurrence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Prediction of local recurrence of ductal carcinoma in situ of the breast using five histological classifications : A comparative study with long follow-up. / Badve, Sunil; A'Hern, Roger P.; Ward, Ann M.; Millis, Rosemary R.; Pinder, Sarah E.; Ellis, Ian O.; Gusterson, Barry A.; Sloane, John P.

In: Human Pathology, Vol. 29, No. 9, 1998, p. 915-923.

Research output: Contribution to journalArticle

Badve, Sunil ; A'Hern, Roger P. ; Ward, Ann M. ; Millis, Rosemary R. ; Pinder, Sarah E. ; Ellis, Ian O. ; Gusterson, Barry A. ; Sloane, John P. / Prediction of local recurrence of ductal carcinoma in situ of the breast using five histological classifications : A comparative study with long follow-up. In: Human Pathology. 1998 ; Vol. 29, No. 9. pp. 915-923.
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