Prediction of Prostatic Involvement by Urothelial Carcinoma in Radical Cystoprostatectomy for Bladder Cancer

Roberta Mazzucchelli, Francesca Barbisan, Alfredo Santinelli, Marina Scarpelli, Andrea B. Galosi, Antonio Lopez-Beltran, Liang Cheng, Ziya Kirkali, Rodolfo Montironi

Research output: Contribution to journalArticle

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Abstract

Objectives: To ascertain which variables of bladder urothelial carcinoma (UC) might be useful in predicting either UC involving the prostate (UCP) or incidental prostate adenocarcinoma in radical cystoprostatectomy specimens. Methods: The bladder and whole-mount prostate sections of 248 radical cystoprostatectomy specimens were reviewed. Stepwise discriminant analysis was used to predict UCP or incidental prostate adenocarcinoma. Results: UCP was present in 94 patients (37.9%). UC originated from the prostatic urethra and periurethral ducts in 78 (31.45%), and isolated direct extension of UC from the bladder was present in 16 patients (6.45%). The periurethral ducts coexisted with direct extension of bladder UC in 11 patients (4.4%). Prostate adenocarcinoma was identified in 123 patients (49.6%). Carcinoma in situ and high-grade urothelial papillary carcinoma were seen in 8 (3.2%) and 5 (2.0%) patients, respectively. In 57 (23%), 64 (25.8%), and 87 (35.1%) patients, UC had invaded the subepithelial connective tissue, muscularis propria, and perivesical tissue, respectively. UC was multifocal in 53 patients (21.4%). The tumor was in the trigone and bladder neck in 160 patients (64.5%). Of the 248 patients, 98 (39.5%) had a history of recurrence. Stepwise discriminant analysis selected 3 variables of bladder UC (previous recurrence and location and number of foci) and correctly predicted the group in 72.2% of patients without and with UCP. Discriminant analysis selected 2 variables of bladder UC (focality and previous recurrence) and correctly predicted the group in 57.7% of patients without and with prostate adenocarcinoma. Conclusions: Our approach can identify bladder UC variables that could guide urologists in the selection of the most appropriate surgical procedure.

Original languageEnglish
Pages (from-to)385-390
Number of pages6
JournalUrology
Volume74
Issue number2
DOIs
StatePublished - Aug 2009

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Urinary Bladder Neoplasms
Prostate
Carcinoma
Urinary Bladder
Adenocarcinoma
Discriminant Analysis
Recurrence
Papillary Carcinoma
Carcinoma in Situ
Urethra
Connective Tissue

ASJC Scopus subject areas

  • Urology

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Mazzucchelli, R., Barbisan, F., Santinelli, A., Scarpelli, M., Galosi, A. B., Lopez-Beltran, A., ... Montironi, R. (2009). Prediction of Prostatic Involvement by Urothelial Carcinoma in Radical Cystoprostatectomy for Bladder Cancer. Urology, 74(2), 385-390. https://doi.org/10.1016/j.urology.2009.03.010

Prediction of Prostatic Involvement by Urothelial Carcinoma in Radical Cystoprostatectomy for Bladder Cancer. / Mazzucchelli, Roberta; Barbisan, Francesca; Santinelli, Alfredo; Scarpelli, Marina; Galosi, Andrea B.; Lopez-Beltran, Antonio; Cheng, Liang; Kirkali, Ziya; Montironi, Rodolfo.

In: Urology, Vol. 74, No. 2, 08.2009, p. 385-390.

Research output: Contribution to journalArticle

Mazzucchelli, R, Barbisan, F, Santinelli, A, Scarpelli, M, Galosi, AB, Lopez-Beltran, A, Cheng, L, Kirkali, Z & Montironi, R 2009, 'Prediction of Prostatic Involvement by Urothelial Carcinoma in Radical Cystoprostatectomy for Bladder Cancer', Urology, vol. 74, no. 2, pp. 385-390. https://doi.org/10.1016/j.urology.2009.03.010
Mazzucchelli R, Barbisan F, Santinelli A, Scarpelli M, Galosi AB, Lopez-Beltran A et al. Prediction of Prostatic Involvement by Urothelial Carcinoma in Radical Cystoprostatectomy for Bladder Cancer. Urology. 2009 Aug;74(2):385-390. https://doi.org/10.1016/j.urology.2009.03.010
Mazzucchelli, Roberta ; Barbisan, Francesca ; Santinelli, Alfredo ; Scarpelli, Marina ; Galosi, Andrea B. ; Lopez-Beltran, Antonio ; Cheng, Liang ; Kirkali, Ziya ; Montironi, Rodolfo. / Prediction of Prostatic Involvement by Urothelial Carcinoma in Radical Cystoprostatectomy for Bladder Cancer. In: Urology. 2009 ; Vol. 74, No. 2. pp. 385-390.
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abstract = "Objectives: To ascertain which variables of bladder urothelial carcinoma (UC) might be useful in predicting either UC involving the prostate (UCP) or incidental prostate adenocarcinoma in radical cystoprostatectomy specimens. Methods: The bladder and whole-mount prostate sections of 248 radical cystoprostatectomy specimens were reviewed. Stepwise discriminant analysis was used to predict UCP or incidental prostate adenocarcinoma. Results: UCP was present in 94 patients (37.9{\%}). UC originated from the prostatic urethra and periurethral ducts in 78 (31.45{\%}), and isolated direct extension of UC from the bladder was present in 16 patients (6.45{\%}). The periurethral ducts coexisted with direct extension of bladder UC in 11 patients (4.4{\%}). Prostate adenocarcinoma was identified in 123 patients (49.6{\%}). Carcinoma in situ and high-grade urothelial papillary carcinoma were seen in 8 (3.2{\%}) and 5 (2.0{\%}) patients, respectively. In 57 (23{\%}), 64 (25.8{\%}), and 87 (35.1{\%}) patients, UC had invaded the subepithelial connective tissue, muscularis propria, and perivesical tissue, respectively. UC was multifocal in 53 patients (21.4{\%}). The tumor was in the trigone and bladder neck in 160 patients (64.5{\%}). Of the 248 patients, 98 (39.5{\%}) had a history of recurrence. Stepwise discriminant analysis selected 3 variables of bladder UC (previous recurrence and location and number of foci) and correctly predicted the group in 72.2{\%} of patients without and with UCP. Discriminant analysis selected 2 variables of bladder UC (focality and previous recurrence) and correctly predicted the group in 57.7{\%} of patients without and with prostate adenocarcinoma. Conclusions: Our approach can identify bladder UC variables that could guide urologists in the selection of the most appropriate surgical procedure.",
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AU - Scarpelli, Marina

AU - Galosi, Andrea B.

AU - Lopez-Beltran, Antonio

AU - Cheng, Liang

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AB - Objectives: To ascertain which variables of bladder urothelial carcinoma (UC) might be useful in predicting either UC involving the prostate (UCP) or incidental prostate adenocarcinoma in radical cystoprostatectomy specimens. Methods: The bladder and whole-mount prostate sections of 248 radical cystoprostatectomy specimens were reviewed. Stepwise discriminant analysis was used to predict UCP or incidental prostate adenocarcinoma. Results: UCP was present in 94 patients (37.9%). UC originated from the prostatic urethra and periurethral ducts in 78 (31.45%), and isolated direct extension of UC from the bladder was present in 16 patients (6.45%). The periurethral ducts coexisted with direct extension of bladder UC in 11 patients (4.4%). Prostate adenocarcinoma was identified in 123 patients (49.6%). Carcinoma in situ and high-grade urothelial papillary carcinoma were seen in 8 (3.2%) and 5 (2.0%) patients, respectively. In 57 (23%), 64 (25.8%), and 87 (35.1%) patients, UC had invaded the subepithelial connective tissue, muscularis propria, and perivesical tissue, respectively. UC was multifocal in 53 patients (21.4%). The tumor was in the trigone and bladder neck in 160 patients (64.5%). Of the 248 patients, 98 (39.5%) had a history of recurrence. Stepwise discriminant analysis selected 3 variables of bladder UC (previous recurrence and location and number of foci) and correctly predicted the group in 72.2% of patients without and with UCP. Discriminant analysis selected 2 variables of bladder UC (focality and previous recurrence) and correctly predicted the group in 57.7% of patients without and with prostate adenocarcinoma. Conclusions: Our approach can identify bladder UC variables that could guide urologists in the selection of the most appropriate surgical procedure.

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