Predictive value of diminutive colonic adenoma trial: The PREDICT trial

Philip Schoenfeld, Javaid Shad, Eric Ormseth, Walter Coyle, Brooks Cash, James Butler, William Schindler, Walter J. Kikendall, Christopher Furlong, Leslie H. Sobin, Christine M. Hobbs, David Cruess, Douglas Rex

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background & Aims: Diminutive adenomas (1-9 mm in diameter) are frequently found during colon cancer screening with flexible sigmoidoscopy (FS). This trial assessed the predictive value of these diminutive adenomas for advanced adenomas in the proximal colon. Methods: In a multicenter, prospective cohort trial, we matched 200 patients with normal FS and 200 patients with diminutive adenomas on FS for age and gender. All patients underwent colonoscopy. The presence of advanced adenomas (adenoma ≥ 10 mm in diameter, villous adenoma, adenoma with high grade dysplasia, and colon cancer) and adenomas (any size) was recorded. Before colonoscopy, patients completed questionnaires about risk factors for adenomas. Results: The prevalence of advanced adenomas in the proximal colon was similar in patients with diminutive adenomas and patients with normal FS (6% vs. 5.5%, respectively) (relative risk, 1.1; 95% confidence interval [Cl], 0.5-2.6). Diminutive adenomas on FS did not accurately predict advanced adenomas in the proximal colon: sensitivity, 52% (95% Cl, 32%-72%); specificity, 50% (95% Cl, 49%-51%); positive predictive value, 6% (95% Cl, 4%-8%); and negative predictive value, 95% (95% Cl, 92%-97%). Male gender (odds ratio, 1.63; 95% Cl, 1.01-2.61) was associated with an increased risk of proximal colon adenomas. Conclusions: Diminutive adenomas on sigmiodoscopy may not accurately predict advanced adenomas in the proximal colon.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalClinical Gastroenterology and Hepatology
Volume1
Issue number3
DOIs
StatePublished - May 1 2003

Fingerprint

Adenoma
Sigmoidoscopy
Colon
Colonoscopy
Colonic Neoplasms
Villous Adenoma
Early Detection of Cancer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Schoenfeld, P., Shad, J., Ormseth, E., Coyle, W., Cash, B., Butler, J., ... Rex, D. (2003). Predictive value of diminutive colonic adenoma trial: The PREDICT trial. Clinical Gastroenterology and Hepatology, 1(3), 195-201. https://doi.org/10.1016/S1542-3565(03)70036-6

Predictive value of diminutive colonic adenoma trial : The PREDICT trial. / Schoenfeld, Philip; Shad, Javaid; Ormseth, Eric; Coyle, Walter; Cash, Brooks; Butler, James; Schindler, William; Kikendall, Walter J.; Furlong, Christopher; Sobin, Leslie H.; Hobbs, Christine M.; Cruess, David; Rex, Douglas.

In: Clinical Gastroenterology and Hepatology, Vol. 1, No. 3, 01.05.2003, p. 195-201.

Research output: Contribution to journalArticle

Schoenfeld, P, Shad, J, Ormseth, E, Coyle, W, Cash, B, Butler, J, Schindler, W, Kikendall, WJ, Furlong, C, Sobin, LH, Hobbs, CM, Cruess, D & Rex, D 2003, 'Predictive value of diminutive colonic adenoma trial: The PREDICT trial', Clinical Gastroenterology and Hepatology, vol. 1, no. 3, pp. 195-201. https://doi.org/10.1016/S1542-3565(03)70036-6
Schoenfeld, Philip ; Shad, Javaid ; Ormseth, Eric ; Coyle, Walter ; Cash, Brooks ; Butler, James ; Schindler, William ; Kikendall, Walter J. ; Furlong, Christopher ; Sobin, Leslie H. ; Hobbs, Christine M. ; Cruess, David ; Rex, Douglas. / Predictive value of diminutive colonic adenoma trial : The PREDICT trial. In: Clinical Gastroenterology and Hepatology. 2003 ; Vol. 1, No. 3. pp. 195-201.
@article{14b142c871324fc6a81d4e73a83f4337,
title = "Predictive value of diminutive colonic adenoma trial: The PREDICT trial",
abstract = "Background & Aims: Diminutive adenomas (1-9 mm in diameter) are frequently found during colon cancer screening with flexible sigmoidoscopy (FS). This trial assessed the predictive value of these diminutive adenomas for advanced adenomas in the proximal colon. Methods: In a multicenter, prospective cohort trial, we matched 200 patients with normal FS and 200 patients with diminutive adenomas on FS for age and gender. All patients underwent colonoscopy. The presence of advanced adenomas (adenoma ≥ 10 mm in diameter, villous adenoma, adenoma with high grade dysplasia, and colon cancer) and adenomas (any size) was recorded. Before colonoscopy, patients completed questionnaires about risk factors for adenomas. Results: The prevalence of advanced adenomas in the proximal colon was similar in patients with diminutive adenomas and patients with normal FS (6{\%} vs. 5.5{\%}, respectively) (relative risk, 1.1; 95{\%} confidence interval [Cl], 0.5-2.6). Diminutive adenomas on FS did not accurately predict advanced adenomas in the proximal colon: sensitivity, 52{\%} (95{\%} Cl, 32{\%}-72{\%}); specificity, 50{\%} (95{\%} Cl, 49{\%}-51{\%}); positive predictive value, 6{\%} (95{\%} Cl, 4{\%}-8{\%}); and negative predictive value, 95{\%} (95{\%} Cl, 92{\%}-97{\%}). Male gender (odds ratio, 1.63; 95{\%} Cl, 1.01-2.61) was associated with an increased risk of proximal colon adenomas. Conclusions: Diminutive adenomas on sigmiodoscopy may not accurately predict advanced adenomas in the proximal colon.",
author = "Philip Schoenfeld and Javaid Shad and Eric Ormseth and Walter Coyle and Brooks Cash and James Butler and William Schindler and Kikendall, {Walter J.} and Christopher Furlong and Sobin, {Leslie H.} and Hobbs, {Christine M.} and David Cruess and Douglas Rex",
year = "2003",
month = "5",
day = "1",
doi = "10.1016/S1542-3565(03)70036-6",
language = "English",
volume = "1",
pages = "195--201",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Predictive value of diminutive colonic adenoma trial

T2 - The PREDICT trial

AU - Schoenfeld, Philip

AU - Shad, Javaid

AU - Ormseth, Eric

AU - Coyle, Walter

AU - Cash, Brooks

AU - Butler, James

AU - Schindler, William

AU - Kikendall, Walter J.

AU - Furlong, Christopher

AU - Sobin, Leslie H.

AU - Hobbs, Christine M.

AU - Cruess, David

AU - Rex, Douglas

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Background & Aims: Diminutive adenomas (1-9 mm in diameter) are frequently found during colon cancer screening with flexible sigmoidoscopy (FS). This trial assessed the predictive value of these diminutive adenomas for advanced adenomas in the proximal colon. Methods: In a multicenter, prospective cohort trial, we matched 200 patients with normal FS and 200 patients with diminutive adenomas on FS for age and gender. All patients underwent colonoscopy. The presence of advanced adenomas (adenoma ≥ 10 mm in diameter, villous adenoma, adenoma with high grade dysplasia, and colon cancer) and adenomas (any size) was recorded. Before colonoscopy, patients completed questionnaires about risk factors for adenomas. Results: The prevalence of advanced adenomas in the proximal colon was similar in patients with diminutive adenomas and patients with normal FS (6% vs. 5.5%, respectively) (relative risk, 1.1; 95% confidence interval [Cl], 0.5-2.6). Diminutive adenomas on FS did not accurately predict advanced adenomas in the proximal colon: sensitivity, 52% (95% Cl, 32%-72%); specificity, 50% (95% Cl, 49%-51%); positive predictive value, 6% (95% Cl, 4%-8%); and negative predictive value, 95% (95% Cl, 92%-97%). Male gender (odds ratio, 1.63; 95% Cl, 1.01-2.61) was associated with an increased risk of proximal colon adenomas. Conclusions: Diminutive adenomas on sigmiodoscopy may not accurately predict advanced adenomas in the proximal colon.

AB - Background & Aims: Diminutive adenomas (1-9 mm in diameter) are frequently found during colon cancer screening with flexible sigmoidoscopy (FS). This trial assessed the predictive value of these diminutive adenomas for advanced adenomas in the proximal colon. Methods: In a multicenter, prospective cohort trial, we matched 200 patients with normal FS and 200 patients with diminutive adenomas on FS for age and gender. All patients underwent colonoscopy. The presence of advanced adenomas (adenoma ≥ 10 mm in diameter, villous adenoma, adenoma with high grade dysplasia, and colon cancer) and adenomas (any size) was recorded. Before colonoscopy, patients completed questionnaires about risk factors for adenomas. Results: The prevalence of advanced adenomas in the proximal colon was similar in patients with diminutive adenomas and patients with normal FS (6% vs. 5.5%, respectively) (relative risk, 1.1; 95% confidence interval [Cl], 0.5-2.6). Diminutive adenomas on FS did not accurately predict advanced adenomas in the proximal colon: sensitivity, 52% (95% Cl, 32%-72%); specificity, 50% (95% Cl, 49%-51%); positive predictive value, 6% (95% Cl, 4%-8%); and negative predictive value, 95% (95% Cl, 92%-97%). Male gender (odds ratio, 1.63; 95% Cl, 1.01-2.61) was associated with an increased risk of proximal colon adenomas. Conclusions: Diminutive adenomas on sigmiodoscopy may not accurately predict advanced adenomas in the proximal colon.

UR - http://www.scopus.com/inward/record.url?scp=10744233287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744233287&partnerID=8YFLogxK

U2 - 10.1016/S1542-3565(03)70036-6

DO - 10.1016/S1542-3565(03)70036-6

M3 - Article

C2 - 15017491

AN - SCOPUS:10744233287

VL - 1

SP - 195

EP - 201

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 3

ER -