Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART

J. Harezlak, R. Cohen, A. Gongvatana, M. Taylor, S. Buchthal, G. Schifitto, J. Zhong, E. S. Daar, J. R. Alger, M. Brown, E. J. Singer, T. B. Campbell, D. McMahon, Y. T. So, C. T. Yiannoutsos, B. A. Navia

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The reasons for persistent brain dysfunction in chronically HIV-infected persons on stable combined antiretroviral therapies (CART) remain unclear. Host and viral factors along with their interactions were examined in 260 HIV-infected subjects who underwent magnetic resonance spectroscopy (MRS). Metabolite concentrations (NAA/Cr, Cho/Cr, MI/Cr, and Glx/Cr) were measured in the basal ganglia, the frontal white matter, and gray matter, and the best predictive models were selected using a bootstrap-enhanced Akaike information criterion (AIC). Depending on the metabolite and brain region, age, race, HIV RNA concentration, ADC stage, duration of HIVinfection, nadir CD4, and/or their interactions were predictive of metabolite concentrations, particularly the basal ganglia NAA/Cr and the mid-frontal NAA/Cr and Glx/Cr, whereas current CD4 and the CPE index rarely or did not predict these changes. These results show for the first time that host and viral factors related to both current and past HIV status contribute to persisting cerebral metabolite abnormalities and provide a framework for further understanding neurological injury in the setting of chronic and stable disease.

Original languageEnglish (US)
Pages (from-to)294-303
Number of pages10
JournalJournal of NeuroVirology
Volume20
Issue number3
DOIs
StatePublished - Jun 2014

Keywords

  • Antiretroviral therapies
  • Biomarkers
  • HIV dementia
  • HIV RNA
  • MRS
  • Neuroimaging

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology
  • Medicine(all)

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    Harezlak, J., Cohen, R., Gongvatana, A., Taylor, M., Buchthal, S., Schifitto, G., Zhong, J., Daar, E. S., Alger, J. R., Brown, M., Singer, E. J., Campbell, T. B., McMahon, D., So, Y. T., Yiannoutsos, C. T., & Navia, B. A. (2014). Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART. Journal of NeuroVirology, 20(3), 294-303. https://doi.org/10.1007/s13365-014-0246-6