Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy

E. F. Chang, M. Quigg, M. C. Oh, W. P. Dillon, M. M. Ward, K. D. Laxer, D. K. Broshek, Nicholas Barbaro

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

BACKGROUND: Stereotactic radiosurgery (RS) is a promising treatment for intractable medial temporal lobe epilepsy (MTLE). However, the basis of its efficacy is not well understood. METHODS: Thirty patients with MTLE were prospectively randomized to receive 20 or 24 Gy 50% isodose RS centered at the amygdala, 2 cm of the anterior hippocampus, and the parahippocampal gyrus. Posttreatment MRI was evaluated quantitatively for abnormal T2 hyperintensity and contrast enhancement, mass effect, and qualitatively for spectroscopic and diffusion changes. MRI findings were analyzed for potential association with radiation dose and seizure remission (Engel Ib or better outcome). RESULTS: Despite highly standardized dose targeting, RS produced variable MRI alterations. In patients with multiple serial imaging, the appearance of vasogenic edema occurred approximately 9-12 months after RS and correlated with onset of seizure remission. Diffusion and spectroscopy-detected alterations were consistent with a mechanism of temporal lobe radiation injury mediated by local vascular insult and neuronal loss. The degree of these early alterations at the peak of radiographic response was dose-dependent and predicted long-term seizure remission in the third year of follow-up. Radiographic changes were not associated with neurocognitive impairments. CONCLUSIONS: Temporal lobe stereotactic radiosurgery resulted in significant seizure reduction in a delayed fashion which appeared to be well-correlated with structural and biochemical alterations observed on neuroimaging. Early detected changes may offer prognostic information for guiding management.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalNeurology
Volume74
Issue number2
DOIs
StatePublished - Jan 2010
Externally publishedYes

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Temporal Lobe Epilepsy
Radiosurgery
Seizures
Temporal Lobe
Parahippocampal Gyrus
Information Management
Radiation Injuries
Amygdala
Neuroimaging
Blood Vessels
Hippocampus
Edema
Spectrum Analysis
Radiation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Chang, E. F., Quigg, M., Oh, M. C., Dillon, W. P., Ward, M. M., Laxer, K. D., ... Barbaro, N. (2010). Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy. Neurology, 74(2), 165-172. https://doi.org/10.1212/WNL.0b013e3181c9185d

Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy. / Chang, E. F.; Quigg, M.; Oh, M. C.; Dillon, W. P.; Ward, M. M.; Laxer, K. D.; Broshek, D. K.; Barbaro, Nicholas.

In: Neurology, Vol. 74, No. 2, 01.2010, p. 165-172.

Research output: Contribution to journalArticle

Chang, EF, Quigg, M, Oh, MC, Dillon, WP, Ward, MM, Laxer, KD, Broshek, DK & Barbaro, N 2010, 'Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy', Neurology, vol. 74, no. 2, pp. 165-172. https://doi.org/10.1212/WNL.0b013e3181c9185d
Chang, E. F. ; Quigg, M. ; Oh, M. C. ; Dillon, W. P. ; Ward, M. M. ; Laxer, K. D. ; Broshek, D. K. ; Barbaro, Nicholas. / Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy. In: Neurology. 2010 ; Vol. 74, No. 2. pp. 165-172.
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