Predictors of herpes simplex virus type 2 antibody positivity among persons with no history of genital herpes

Kenneth Fife, David I. Bernstein, Wanzhu Tu, Gregory Zimet, Rebecca Brady, Jingwei Wu, J. Fortenberry, Katherine M. Stone, Susan L. Rosenthal, Lawrence R. Stanberry

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The demographic, historical, and behavioral factors that predict a positive herpes simplex virus type 2 (HSV-2) antibody test in persons without a history of genital herpes have not been well-defined. Methods: Individuals (age 14-30 years) without a history of genital herpes completed a questionnaire and were offered free HSV-2 antibody testing. Factors from the questionnaire were correlated with the HSV-2 antibody result. Results: Univariate analysis showed that female gender was significantly associated with positive test results. In gender-specific, multiple logistic regression models, a positive HSV-2 antibody test among men was associated with older age, non-white race, and a history of sexually transmitted disease (STD). Gender-specific symptom scores from the questionnaire were not predictive in either gender, but the gender-common symptom score was marginally predictive of a positive HSV-2 antibody test in women. Among women, older age, non-white race, and STD history predicted a positive test. Conclusions: Among young persons with no history of genital herpes who agreed to HSV-2 antibody testing, increasing age, non-white race, and a history of an STD were predictors of a positive test. A history of frequent pain, itching, burning, and rashes in the anogenital region was marginally associated with positive HSV-2 tests in women. These results might help guide selective use of HSV-2 antibody screening.

Original languageEnglish
Pages (from-to)676-681
Number of pages6
JournalSexually Transmitted Diseases
Volume31
Issue number11
DOIs
StatePublished - Nov 2004

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Herpes Genitalis
Human Herpesvirus 2
Antibodies
Sexually Transmitted Diseases
Logistic Models
Pruritus
Exanthema
Demography
Pain

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)

Cite this

Predictors of herpes simplex virus type 2 antibody positivity among persons with no history of genital herpes. / Fife, Kenneth; Bernstein, David I.; Tu, Wanzhu; Zimet, Gregory; Brady, Rebecca; Wu, Jingwei; Fortenberry, J.; Stone, Katherine M.; Rosenthal, Susan L.; Stanberry, Lawrence R.

In: Sexually Transmitted Diseases, Vol. 31, No. 11, 11.2004, p. 676-681.

Research output: Contribution to journalArticle

Fife, Kenneth ; Bernstein, David I. ; Tu, Wanzhu ; Zimet, Gregory ; Brady, Rebecca ; Wu, Jingwei ; Fortenberry, J. ; Stone, Katherine M. ; Rosenthal, Susan L. ; Stanberry, Lawrence R. / Predictors of herpes simplex virus type 2 antibody positivity among persons with no history of genital herpes. In: Sexually Transmitted Diseases. 2004 ; Vol. 31, No. 11. pp. 676-681.
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