Predictors of mortality over 8 years in type 2 diabetic patients: Translating research into action for diabetes (TRIAD)

Laura N. McEwen, David G. Marrero, Andrew J. Karter, Carol M. Mangione, Beth E. Waitzfelder, William H. Herman, Jesse C. Crosson

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

OBJECTIVE - To examine demographic, socioeconomic, and biological risk factors for all-cause, cardiovascular, and noncardiovascular mortality in patients with type 2 diabetes over 8 years and to construct mortality prediction equations. RESEARCH DESIGN AND METHODS - Beginning in 2000, survey and medical record information was obtained from 8,334 participants in Translating Research Into Action for Diabetes (TRIAD), a multicenter prospective observational study of diabetes care in managed care. The National Death Index was searched annually to obtain data on deaths over an 8-year follow-up period (2000-2007). Predictors examined included age, sex, race, education, income, smoking, age at diagnosis of diabetes, duration and treatment of diabetes, BMI, complications, comorbidities, and medication use. RESULTS - There were 1,616 (19%) deaths over the 8-year period. In the most parsimonious equation, the predictors of all-cause mortality included older age, male sex, white race, lower income, smoking, insulin treatment, nephropathy, history of dyslipidemia, higher LDL cholesterol, angina/myocardial infarction/other coronary disease/coronary angioplasty/bypass, congestive heart failure, aspirin, β-blocker, and diuretic use, and higher Charlson Index. CONCLUSIONS - Risk of death can be predicted in people with type 2 diabetes using simple demographic, socioeconomic, and biological risk factors with fair reliability. Such prediction equations are essential for computer simulation models of diabetes progression and may, with further validation, be useful for patient management.

Original languageEnglish (US)
Pages (from-to)1301-1309
Number of pages9
JournalDiabetes care
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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    McEwen, L. N., Marrero, D. G., Karter, A. J., Mangione, C. M., Waitzfelder, B. E., Herman, W. H., & Crosson, J. C. (2012). Predictors of mortality over 8 years in type 2 diabetic patients: Translating research into action for diabetes (TRIAD). Diabetes care, 35(6), 1301-1309. https://doi.org/10.2337/dc11-2281