Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy

Alberto Cerra-Franco; Sheng Liu; Michella Azar; Kevin Shiue; Samantha Freije; Jason Hinton; Christopher R. Deig; Donna Edwards; Neil C. Estabrook; Susannah G. Ellsworth; Ke Huang; Khalil Diab; Mark P. Langer; Richard Zellars; Feng Ming Kong; Jun Wan; Tim Lautenschlaeger

doi:10.1016/j.cllc.2018.12.016

Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy

Alberto Cerra-Franco, Sheng Liu, Michella Azar, Kevin Shiue, Samantha Freije, Jason Hinton, Christopher R. Deig, Donna Edwards, Neil C. Estabrook, Susannah G. Ellsworth, Ke Huang, Khalil Diab, Mark P. Langer, Richard Zellars, Feng Ming Kong, Jun Wan, Tim Lautenschlaeger

Research output: Contribution to journal › Article

Abstract

Many patients with early stage non–small-cell lung cancer develop metastases after stereotactic body radiation therapy. We retrospectively analyzed multiple variables in 406 lesions to develop a predictor for metastatic failure. Gross tumor volume and prescription dose were significantly associated with metastases. A metastasis risk score tool was developed to identify patients at higher risk for metastases after lung stereotactic body radiation therapy who might benefit from enrollment in future trials evaluating the benefit of adjuvant or intensified treatment.

Original language	English (US)
Pages (from-to)	186-193.e3
Journal	Clinical Lung Cancer
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.cllc.2018.12.016
State	Published - May 2019

Keywords

Metastasis
SABR
SBRT
Stereotactic body ablative radiotherapy
Stereotactic body radiation therapy

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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Cerra-Franco, A., Liu, S., Azar, M., Shiue, K., Freije, S., Hinton, J., Deig, C. R., Edwards, D., Estabrook, N. C., Ellsworth, S. G., Huang, K., Diab, K., Langer, M. P., Zellars, R., Kong, F. M., Wan, J., & Lautenschlaeger, T. (2019). Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy. Clinical Lung Cancer, 20(3), 186-193.e3. https://doi.org/10.1016/j.cllc.2018.12.016

Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy. / Cerra-Franco, Alberto; Liu, Sheng; Azar, Michella; Shiue, Kevin; Freije, Samantha; Hinton, Jason; Deig, Christopher R.; Edwards, Donna; Estabrook, Neil C.; Ellsworth, Susannah G.; Huang, Ke; Diab, Khalil; Langer, Mark P.; Zellars, Richard; Kong, Feng Ming; Wan, Jun; Lautenschlaeger, Tim.

In: Clinical Lung Cancer, Vol. 20, No. 3, 05.2019, p. 186-193.e3.

Research output: Contribution to journal › Article

Cerra-Franco, A, Liu, S, Azar, M, Shiue, K, Freije, S, Hinton, J, Deig, CR, Edwards, D, Estabrook, NC, Ellsworth, SG, Huang, K, Diab, K, Langer, MP, Zellars, R, Kong, FM, Wan, J & Lautenschlaeger, T 2019, 'Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy', Clinical Lung Cancer, vol. 20, no. 3, pp. 186-193.e3. https://doi.org/10.1016/j.cllc.2018.12.016

Cerra-Franco, Alberto ; Liu, Sheng ; Azar, Michella ; Shiue, Kevin ; Freije, Samantha ; Hinton, Jason ; Deig, Christopher R. ; Edwards, Donna ; Estabrook, Neil C. ; Ellsworth, Susannah G. ; Huang, Ke ; Diab, Khalil ; Langer, Mark P. ; Zellars, Richard ; Kong, Feng Ming ; Wan, Jun ; Lautenschlaeger, Tim. / Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy. In: Clinical Lung Cancer. 2019 ; Vol. 20, No. 3. pp. 186-193.e3.

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abstract = "Many patients with early stage non–small-cell lung cancer develop metastases after stereotactic body radiation therapy. We retrospectively analyzed multiple variables in 406 lesions to develop a predictor for metastatic failure. Gross tumor volume and prescription dose were significantly associated with metastases. A metastasis risk score tool was developed to identify patients at higher risk for metastases after lung stereotactic body radiation therapy who might benefit from enrollment in future trials evaluating the benefit of adjuvant or intensified treatment.",

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AU - Freije, Samantha

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