Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy

Alberto Cerra-Franco; Sheng Liu; Michella Azar; Kevin Shiue; Samantha Freije; Jason Hinton; Christopher R. Deig; Donna Edwards; Neil C. Estabrook; Susannah G. Ellsworth; Ke Huang; Khalil Diab; Mark P. Langer; Richard Zellars; Feng Ming Kong; Jun Wan; Tim Lautenschlaeger

doi:10.1016/j.cllc.2018.12.016

Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy

Alberto Cerra-Franco, Sheng Liu, Michella Azar, Kevin Shiue, Samantha Freije, Jason Hinton, Christopher R. Deig, Donna Edwards, Neil C. Estabrook, Susannah G. Ellsworth, Ke Huang, Khalil Diab, Mark P. Langer, Richard Zellars, Feng Ming Kong, Jun Wan, Tim Lautenschlaeger

Research output: Contribution to journal › Article

Abstract

Many patients with early stage non–small-cell lung cancer develop metastases after stereotactic body radiation therapy. We retrospectively analyzed multiple variables in 406 lesions to develop a predictor for metastatic failure. Gross tumor volume and prescription dose were significantly associated with metastases. A metastasis risk score tool was developed to identify patients at higher risk for metastases after lung stereotactic body radiation therapy who might benefit from enrollment in future trials evaluating the benefit of adjuvant or intensified treatment.

Original language	English (US)
Pages (from-to)	186-193.e3
Journal	Clinical Lung Cancer
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.cllc.2018.12.016
State	Published - May 2019

Fingerprint

Keywords

Metastasis
SABR
SBRT
Stereotactic body ablative radiotherapy
Stereotactic body radiation therapy

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

Cite this

Cerra-Franco, A., Liu, S., Azar, M., Shiue, K., Freije, S., Hinton, J., Deig, C. R., Edwards, D., Estabrook, N. C., Ellsworth, S. G., Huang, K., Diab, K., Langer, M. P., Zellars, R., Kong, F. M., Wan, J., & Lautenschlaeger, T. (2019). Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy. Clinical Lung Cancer, 20(3), 186-193.e3. https://doi.org/10.1016/j.cllc.2018.12.016

Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy. / Cerra-Franco, Alberto; Liu, Sheng; Azar, Michella; Shiue, Kevin; Freije, Samantha; Hinton, Jason; Deig, Christopher R.; Edwards, Donna; Estabrook, Neil C.; Ellsworth, Susannah G.; Huang, Ke; Diab, Khalil; Langer, Mark P.; Zellars, Richard; Kong, Feng Ming; Wan, Jun; Lautenschlaeger, Tim.

In: Clinical Lung Cancer, Vol. 20, No. 3, 05.2019, p. 186-193.e3.

Research output: Contribution to journal › Article

Cerra-Franco, A, Liu, S, Azar, M, Shiue, K, Freije, S, Hinton, J, Deig, CR, Edwards, D, Estabrook, NC, Ellsworth, SG, Huang, K, Diab, K, Langer, MP, Zellars, R, Kong, FM, Wan, J & Lautenschlaeger, T 2019, 'Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy', Clinical Lung Cancer, vol. 20, no. 3, pp. 186-193.e3. https://doi.org/10.1016/j.cllc.2018.12.016

Cerra-Franco, Alberto ; Liu, Sheng ; Azar, Michella ; Shiue, Kevin ; Freije, Samantha ; Hinton, Jason ; Deig, Christopher R. ; Edwards, Donna ; Estabrook, Neil C. ; Ellsworth, Susannah G. ; Huang, Ke ; Diab, Khalil ; Langer, Mark P. ; Zellars, Richard ; Kong, Feng Ming ; Wan, Jun ; Lautenschlaeger, Tim. / Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy. In: Clinical Lung Cancer. 2019 ; Vol. 20, No. 3. pp. 186-193.e3.

@article{179a2b78a7e64636a6cea332c1c9faf7,

title = "Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy",

abstract = "Many patients with early stage non–small-cell lung cancer develop metastases after stereotactic body radiation therapy. We retrospectively analyzed multiple variables in 406 lesions to develop a predictor for metastatic failure. Gross tumor volume and prescription dose were significantly associated with metastases. A metastasis risk score tool was developed to identify patients at higher risk for metastases after lung stereotactic body radiation therapy who might benefit from enrollment in future trials evaluating the benefit of adjuvant or intensified treatment.",

keywords = "Metastasis, SABR, SBRT, Stereotactic body ablative radiotherapy, Stereotactic body radiation therapy",

author = "Alberto Cerra-Franco and Sheng Liu and Michella Azar and Kevin Shiue and Samantha Freije and Jason Hinton and Deig, {Christopher R.} and Donna Edwards and Estabrook, {Neil C.} and Ellsworth, {Susannah G.} and Ke Huang and Khalil Diab and Langer, {Mark P.} and Richard Zellars and Kong, {Feng Ming} and Jun Wan and Tim Lautenschlaeger",

year = "2019",

month = may

doi = "10.1016/j.cllc.2018.12.016",

language = "English (US)",

volume = "20",

pages = "186--193.e3",

journal = "Clinical Lung Cancer",

issn = "1525-7304",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Predictors of Nodal and Metastatic Failure in Early Stage Non–small-cell Lung Cancer After Stereotactic Body Radiation Therapy

AU - Cerra-Franco, Alberto

AU - Liu, Sheng

AU - Azar, Michella

AU - Shiue, Kevin

AU - Freije, Samantha

AU - Hinton, Jason

AU - Deig, Christopher R.

AU - Edwards, Donna

AU - Estabrook, Neil C.

AU - Ellsworth, Susannah G.

AU - Huang, Ke

AU - Diab, Khalil

AU - Langer, Mark P.

AU - Zellars, Richard

AU - Kong, Feng Ming

AU - Wan, Jun

AU - Lautenschlaeger, Tim

PY - 2019/5

Y1 - 2019/5

N2 - Many patients with early stage non–small-cell lung cancer develop metastases after stereotactic body radiation therapy. We retrospectively analyzed multiple variables in 406 lesions to develop a predictor for metastatic failure. Gross tumor volume and prescription dose were significantly associated with metastases. A metastasis risk score tool was developed to identify patients at higher risk for metastases after lung stereotactic body radiation therapy who might benefit from enrollment in future trials evaluating the benefit of adjuvant or intensified treatment.

AB - Many patients with early stage non–small-cell lung cancer develop metastases after stereotactic body radiation therapy. We retrospectively analyzed multiple variables in 406 lesions to develop a predictor for metastatic failure. Gross tumor volume and prescription dose were significantly associated with metastases. A metastasis risk score tool was developed to identify patients at higher risk for metastases after lung stereotactic body radiation therapy who might benefit from enrollment in future trials evaluating the benefit of adjuvant or intensified treatment.

KW - Metastasis

KW - SABR

KW - SBRT

KW - Stereotactic body ablative radiotherapy

KW - Stereotactic body radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=85060722365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060722365&partnerID=8YFLogxK

U2 - 10.1016/j.cllc.2018.12.016

DO - 10.1016/j.cllc.2018.12.016

M3 - Article

C2 - 30711394

AN - SCOPUS:85060722365

VL - 20

SP - 186-193.e3

JO - Clinical Lung Cancer

JF - Clinical Lung Cancer

SN - 1525-7304

IS - 3

ER -

Access to Document

10.1016/j.cllc.2018.12.016