Predictors of ovarian malignancy in children: Overcoming clinical barriers of ovarian preservation

Jonathan C. Papic, S. Maria Finnell, James E. Slaven, Deborah F. Billmire, Frederick Rescorla, Charles M. Leys

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background/Purpose Ovarian preservation is desirable in girls with benign ovarian masses. We aimed to 1) identify clinical predictors of malignant ovarian masses, 2) investigate how often ovarian tissue is present to preserve in benign masses, and 3) identify factors associated with successful ovarian preservation. Methods Retrospective analysis (1997-2012) of girls age 1-18 years with an ovarian mass managed operatively. Data on presenting symptoms, imaging, biochemical markers, treatment, outcome, and pathology were extracted. Results We identified 150 patients. Large mass size, solid components, and elevated tumor markers (AFP, βHCG, and/or LDH) were significantly predictive of malignancy. All masses < 10 cm, predominantly cystic, and with negative tumor markers were benign. Masses with all three of these characteristics would decrease a 20% malignancy pretest probability to a posttest probability of 0.25%. Benign masses managed by oophorectomy contained normal ovarian tissue in 76% of the specimens. For benign masses, successful ovarian preservation was significantly associated with size < 10 cm, predominantly cystic, laparoscopy, and absence of torsion or calcifications. Conclusion Ovarian masses that are < 10 cm, primarily cystic, and have negative tumor markers are most likely benign. Viable ovarian tissue is frequently present in benign masses, so significant efforts should be made for ovarian preservation.

Original languageEnglish
Pages (from-to)144-148
Number of pages5
JournalJournal of Pediatric Surgery
Volume49
Issue number1
DOIs
StatePublished - Jan 2014

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Tumor Biomarkers
Neoplasms
Ovariectomy
Laparoscopy
Biomarkers
Pathology

Keywords

  • Children
  • Fertility sparing
  • Ovarian malignancy
  • Ovarian mass
  • Ovarian preservation

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Predictors of ovarian malignancy in children : Overcoming clinical barriers of ovarian preservation. / Papic, Jonathan C.; Finnell, S. Maria; Slaven, James E.; Billmire, Deborah F.; Rescorla, Frederick; Leys, Charles M.

In: Journal of Pediatric Surgery, Vol. 49, No. 1, 01.2014, p. 144-148.

Research output: Contribution to journalArticle

Papic, Jonathan C. ; Finnell, S. Maria ; Slaven, James E. ; Billmire, Deborah F. ; Rescorla, Frederick ; Leys, Charles M. / Predictors of ovarian malignancy in children : Overcoming clinical barriers of ovarian preservation. In: Journal of Pediatric Surgery. 2014 ; Vol. 49, No. 1. pp. 144-148.
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