Predictors of successful outcome after cholecystectomy for biliary dyskinesia

David E. Carney, Evan R. Kokoska, Jay L. Grosfeld, Scott A. Engum, Thomas M. Rouse, Karen M. West, Alan Ladd, Frederick J. Rescorla

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Purpose Laparoscopic cholecystectomy is accepted therapy for children with ill-defined abdominal pain and impaired gallbladder emptying (biliary dyskinesia). Follow-up shows poor clinical response in many of these patients. The purpose of this report is to identify clinical and radiographic predictors of successful outcome after cholecystectomy for biliary dyskinesia. Methods The authors retrospectively reviewed records of 51 children after laparoscopic cholecystectomy for biliary dyskinesia (1990 to 2003). Clinical symptoms, radiographic findings, and pathology were evaluated. Subjective clinical improvement is stratified using an established patient satisfaction score. Logistic regression analysis determines statistically independent predictors of successful outcome. Results Thirty-eight of 51 (75%) patients were available for follow-up. Twenty-seven of 38 (71%) patients reported complete resolution of symptoms. Nausea was the only symptom predictive of successful outcome by univariate analysis (odds ratio, 5.00). A cholecystokinin-stimulated, gallbladder ejection fraction less than 15% also predicts successful outcome (odds ratio, 8.00). Children with an ejection fraction greater than 15% did not have predictable resolution of symptoms. When present with pain and nausea, gallbladder emptying less than 15% has a positive predictive value of 93% and a negative predictive value of 81%. Conclusions Together, nausea, pain, and decreased gallbladder emptying (<15%) most reliably predict which children will benefit from cholecystectomy for biliary dyskinesia.

Original languageEnglish (US)
Pages (from-to)813-816
Number of pages4
JournalJournal of pediatric surgery
Volume39
Issue number6
DOIs
StatePublished - Jun 2004

Keywords

  • Biliary dyskinesia
  • cholecystokinin-stimulated ejection fraction
  • laparoscopic cholecystectomy

ASJC Scopus subject areas

  • Surgery

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    Carney, D. E., Kokoska, E. R., Grosfeld, J. L., Engum, S. A., Rouse, T. M., West, K. M., Ladd, A., & Rescorla, F. J. (2004). Predictors of successful outcome after cholecystectomy for biliary dyskinesia. Journal of pediatric surgery, 39(6), 813-816. https://doi.org/10.1016/j.jpedsurg.2004.02.017