Prednisone decreases CSF somatostatin in healthy humans

Implications for neuropsychiatric illness

Owen M. Wolkowitz, David R. Rubinow, Alan Breier, Allen R. Doran, Candy Davis, David Pickar

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Several neuropsychiatric illness, including depression and Alzheimer's disease, are reported to be characterized by hypercortisolemia and by reduced levels of cerebrospinal fluid somatostatin-like immunoreactivity (CSF-SLI). To investigate a possible causal linkage between these abnormalities we administered prednisone, 80 mg orally per day for 5 days, to 9 healthy volunteers. We observed significant prednisone-induced reductions in CSF-SLI. Moreover, the magnitude of these reductions was inversely related to the magnitude of prednisone-induced reductions in plasma ACTH levels, suggesting a functional interaction between circulating corticosteroids, central somatostatin and pituitary ACTH release.

Original languageEnglish (US)
Pages (from-to)1929-1933
Number of pages5
JournalLife Sciences
Volume41
Issue number16
DOIs
StatePublished - Oct 19 1987
Externally publishedYes

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Prednisone
Somatostatin
Cerebrospinal fluid
Adrenocorticotropic Hormone
Cerebrospinal Fluid
Beam plasma interactions
Healthy Volunteers
Alzheimer Disease
Adrenal Cortex Hormones
Depression
Plasmas
somatostatin-like peptides

ASJC Scopus subject areas

  • Pharmacology

Cite this

Prednisone decreases CSF somatostatin in healthy humans : Implications for neuropsychiatric illness. / Wolkowitz, Owen M.; Rubinow, David R.; Breier, Alan; Doran, Allen R.; Davis, Candy; Pickar, David.

In: Life Sciences, Vol. 41, No. 16, 19.10.1987, p. 1929-1933.

Research output: Contribution to journalArticle

Wolkowitz, Owen M. ; Rubinow, David R. ; Breier, Alan ; Doran, Allen R. ; Davis, Candy ; Pickar, David. / Prednisone decreases CSF somatostatin in healthy humans : Implications for neuropsychiatric illness. In: Life Sciences. 1987 ; Vol. 41, No. 16. pp. 1929-1933.
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