Prednisone decreases CSF somatostatin in healthy humans: Implications for neuropsychiatric illness

Owen M. Wolkowitz, David R. Rubinow, Alan Breier, Allen R. Doran, Candy Davis, David Pickar

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Several neuropsychiatric illness, including depression and Alzheimer's disease, are reported to be characterized by hypercortisolemia and by reduced levels of cerebrospinal fluid somatostatin-like immunoreactivity (CSF-SLI). To investigate a possible causal linkage between these abnormalities we administered prednisone, 80 mg orally per day for 5 days, to 9 healthy volunteers. We observed significant prednisone-induced reductions in CSF-SLI. Moreover, the magnitude of these reductions was inversely related to the magnitude of prednisone-induced reductions in plasma ACTH levels, suggesting a functional interaction between circulating corticosteroids, central somatostatin and pituitary ACTH release.

Original languageEnglish (US)
Pages (from-to)1929-1933
Number of pages5
JournalLife Sciences
Volume41
Issue number16
DOIs
StatePublished - Oct 19 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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