Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas

J. M. Cheng, Jill Reiter, S. S. Schneider, A. Naumova, N. K V Cheung, S. L. Cohn, L. Diller, C. Sapienza, G. M. Brodeur

Research output: Contribution to journalArticle

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Abstract

Genomic imprinting plays a role in influencing the parental origin of genes involved in cancer-specific rearrangements. We have analysed 22 neuroblastomas with N-myc amplification to determine the parental origin of the amplified N-myc allele and the allele that is deleted from chromosome 1p. We analysed DNA from neuroblastoma patients and their parents, using four polymorphisms for 1p and three for the N-myc amplicon. We determined that the paternal allele of N-myc was preferentially amplified (12 out of 13 cases; P = 0.002). However, the paternal allele was lost from 1p in six out of ten cases, consistent with a random distribution (P > 0.2). These results suggest that parental imprinting influences which N-myc allele is amplified in neuroblastomas, but it does not appear to affect the 1p allele that is deleted in the cases that we have examined.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalNature Genetics
Volume4
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

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myc Genes
Neuroblastoma
Alleles
Genomic Imprinting
Chromosomes
Parents
DNA
Genes
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Cheng, J. M., Reiter, J., Schneider, S. S., Naumova, A., Cheung, N. K. V., Cohn, S. L., ... Brodeur, G. M. (1993). Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas. Nature Genetics, 4(2), 191-194. https://doi.org/10.1038/ng0693-191

Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas. / Cheng, J. M.; Reiter, Jill; Schneider, S. S.; Naumova, A.; Cheung, N. K V; Cohn, S. L.; Diller, L.; Sapienza, C.; Brodeur, G. M.

In: Nature Genetics, Vol. 4, No. 2, 1993, p. 191-194.

Research output: Contribution to journalArticle

Cheng, JM, Reiter, J, Schneider, SS, Naumova, A, Cheung, NKV, Cohn, SL, Diller, L, Sapienza, C & Brodeur, GM 1993, 'Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas', Nature Genetics, vol. 4, no. 2, pp. 191-194. https://doi.org/10.1038/ng0693-191
Cheng, J. M. ; Reiter, Jill ; Schneider, S. S. ; Naumova, A. ; Cheung, N. K V ; Cohn, S. L. ; Diller, L. ; Sapienza, C. ; Brodeur, G. M. / Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas. In: Nature Genetics. 1993 ; Vol. 4, No. 2. pp. 191-194.
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