Preferential amplification of the paternal allele of the N–myc gene in human neuroblastomas

Judy M. Cheng, Jill L. Hiemstra, Sandra S. Schneider, Anna Naumova, Nai Kong V. Cheung, Susan L. Cohn, Lisa Diller, Carmen Sapienza, Garrett M. Brodeur

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Genomic imprinting plays a role in influencing the parental origin of genes involved in cancer–specific rearrangements. We have analysed 22 neuroblastomas with N–myc amplification to determine the parental origin of the amplified N–myc allele and the allele that is deleted from chromosome 1p. We analysed DNA from neuroblastoma patients and their parents, using four polymorphisms for 1 p and three for the N–myc amplicon. We determined that the paternal allele of N–myc was preferentially amplified (12 out of 13 cases; P = 0.002). However, the paternal allele was lost from 1 p in six out of ten cases, consistent with a random distribution (P > 0.2). These results suggest that parental imprinting influences which N–myc allele is amplified in neuroblastomas, but it does not appear to affect the 1p allele that is deleted in the cases that we have examined.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalNature genetics
Volume4
Issue number2
DOIs
StatePublished - Jun 1993
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Preferential amplification of the paternal allele of the N–myc gene in human neuroblastomas'. Together they form a unique fingerprint.

  • Cite this

    Cheng, J. M., Hiemstra, J. L., Schneider, S. S., Naumova, A., Cheung, N. K. V., Cohn, S. L., Diller, L., Sapienza, C., & Brodeur, G. M. (1993). Preferential amplification of the paternal allele of the N–myc gene in human neuroblastomas. Nature genetics, 4(2), 191-194. https://doi.org/10.1038/ng0693-191