Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing

Jasmeer P. Chhatwal, Aaron P. Schultz, Keith A. Johnson, Trey Hedden, Sehily Jaimes, Tammie L.S. Benzinger, Clifford Jack, Beau M. Ances, John M. Ringman, Daniel S. Marcus, Bernardino Ghetti, Martin Farlow, Adrian Danek, Johannes Levin, Igor Yakushev, Christoph Laske, Robert A. Koeppe, Douglas R. Galasko, Chengjie Xiong, Colin L. MastersPeter R. Schofield, Kirsi M. Kinnunen, Stephen Salloway, Ralph N. Martins, Eric McDade, Nigel J. Cairns, Virginia D. Buckles, John C. Morris, Randall Bateman, Reisa A. Sperling

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Converging evidence from structural, metabolic and functional connectivity MRI suggests that neurodegenerative diseases, such as Alzheimer's disease, target specific neural networks. However, age-related network changes commonly co-occur with neuropathological cascades, limiting efforts to disentangle disease-specific alterations in network function from those associated with normal ageing. Here we elucidate the differential effects of ageing and Alzheimer's disease pathology through simultaneous analyses of two functional connectivity MRI datasets: (i) young participants harbouring highly-penetrant mutations leading to autosomal-dominant Alzheimer's disease from the Dominantly Inherited Alzheimer's Network (DIAN), an Alzheimer's disease cohort in which age-related comorbidities are minimal and likelihood of progression along an Alzheimer's disease trajectory is extremely high; and (ii) young and elderly participants from the Harvard Aging Brain Study, a cohort in which imaging biomarkers of amyloid burden and neurodegeneration can be used to disambiguate ageing alone from preclinical Alzheimer's disease. Consonant with prior reports, we observed the preferential degradation of cognitive (especially the default and dorsal attention networks) over motor and sensory networks in early autosomal-dominant Alzheimer's disease, and found that this distinctive degradation pattern was magnified in more advanced stages of disease. Importantly, a nascent form of the pattern observed across the autosomal-dominant Alzheimer's disease spectrum was also detectable in clinically normal elderly with clear biomarker evidence of Alzheimer's disease pathology (preclinical Alzheimer's disease). At the more granular level of individual connections between node pairs, we observed that connections within cognitive networks were preferentially targeted in Alzheimer's disease (with between network connections relatively spared), and that connections between positively coupled nodes (correlations) were preferentially degraded as compared to connections between negatively coupled nodes (anti-correlations). In contrast, ageing in the absence of Alzheimer's disease biomarkers was characterized by a far less network-specific degradation across cognitive and sensory networks, of between- and within-network connections, and of connections between positively and negatively coupled nodes. We go on to demonstrate that formalizing the differential patterns of network degradation in ageing and Alzheimer's disease may have the practical benefit of yielding connectivity measurements that highlight early Alzheimer's disease-related connectivity changes over those due to age-related processes. Together, the contrasting patterns of connectivity in Alzheimer's disease and ageing add to prior work arguing against Alzheimer's disease as a form of accelerated ageing, and suggest multi-network composite functional connectivity MRI metrics may be useful in the detection of early Alzheimer's disease-specific alterations co-occurring with age-related connectivity changes. More broadly, our findings are consistent with a specific pattern of network degradation associated with the spreading of Alzheimer's disease pathology within targeted neural networks.

Original languageEnglish (US)
Pages (from-to)1486-1500
Number of pages15
JournalBrain
Volume141
Issue number5
DOIs
StatePublished - May 1 2018

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Alzheimer Disease
Biomarkers
Magnetic Resonance Imaging
Pathology
Amyloid
Neurodegenerative Diseases
Comorbidity
Cohort Studies

Keywords

  • Alzheimer's disease
  • amyloid imaging
  • dementia
  • functional connectivity

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Chhatwal, J. P., Schultz, A. P., Johnson, K. A., Hedden, T., Jaimes, S., Benzinger, T. L. S., ... Sperling, R. A. (2018). Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing. Brain, 141(5), 1486-1500. https://doi.org/10.1093/brain/awy053

Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing. / Chhatwal, Jasmeer P.; Schultz, Aaron P.; Johnson, Keith A.; Hedden, Trey; Jaimes, Sehily; Benzinger, Tammie L.S.; Jack, Clifford; Ances, Beau M.; Ringman, John M.; Marcus, Daniel S.; Ghetti, Bernardino; Farlow, Martin; Danek, Adrian; Levin, Johannes; Yakushev, Igor; Laske, Christoph; Koeppe, Robert A.; Galasko, Douglas R.; Xiong, Chengjie; Masters, Colin L.; Schofield, Peter R.; Kinnunen, Kirsi M.; Salloway, Stephen; Martins, Ralph N.; McDade, Eric; Cairns, Nigel J.; Buckles, Virginia D.; Morris, John C.; Bateman, Randall; Sperling, Reisa A.

In: Brain, Vol. 141, No. 5, 01.05.2018, p. 1486-1500.

Research output: Contribution to journalArticle

Chhatwal, JP, Schultz, AP, Johnson, KA, Hedden, T, Jaimes, S, Benzinger, TLS, Jack, C, Ances, BM, Ringman, JM, Marcus, DS, Ghetti, B, Farlow, M, Danek, A, Levin, J, Yakushev, I, Laske, C, Koeppe, RA, Galasko, DR, Xiong, C, Masters, CL, Schofield, PR, Kinnunen, KM, Salloway, S, Martins, RN, McDade, E, Cairns, NJ, Buckles, VD, Morris, JC, Bateman, R & Sperling, RA 2018, 'Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing', Brain, vol. 141, no. 5, pp. 1486-1500. https://doi.org/10.1093/brain/awy053
Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS et al. Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing. Brain. 2018 May 1;141(5):1486-1500. https://doi.org/10.1093/brain/awy053
Chhatwal, Jasmeer P. ; Schultz, Aaron P. ; Johnson, Keith A. ; Hedden, Trey ; Jaimes, Sehily ; Benzinger, Tammie L.S. ; Jack, Clifford ; Ances, Beau M. ; Ringman, John M. ; Marcus, Daniel S. ; Ghetti, Bernardino ; Farlow, Martin ; Danek, Adrian ; Levin, Johannes ; Yakushev, Igor ; Laske, Christoph ; Koeppe, Robert A. ; Galasko, Douglas R. ; Xiong, Chengjie ; Masters, Colin L. ; Schofield, Peter R. ; Kinnunen, Kirsi M. ; Salloway, Stephen ; Martins, Ralph N. ; McDade, Eric ; Cairns, Nigel J. ; Buckles, Virginia D. ; Morris, John C. ; Bateman, Randall ; Sperling, Reisa A. / Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing. In: Brain. 2018 ; Vol. 141, No. 5. pp. 1486-1500.
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AU - Benzinger, Tammie L.S.

AU - Jack, Clifford

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AU - Ringman, John M.

AU - Marcus, Daniel S.

AU - Ghetti, Bernardino

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AU - Danek, Adrian

AU - Levin, Johannes

AU - Yakushev, Igor

AU - Laske, Christoph

AU - Koeppe, Robert A.

AU - Galasko, Douglas R.

AU - Xiong, Chengjie

AU - Masters, Colin L.

AU - Schofield, Peter R.

AU - Kinnunen, Kirsi M.

AU - Salloway, Stephen

AU - Martins, Ralph N.

AU - McDade, Eric

AU - Cairns, Nigel J.

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N2 - Converging evidence from structural, metabolic and functional connectivity MRI suggests that neurodegenerative diseases, such as Alzheimer's disease, target specific neural networks. However, age-related network changes commonly co-occur with neuropathological cascades, limiting efforts to disentangle disease-specific alterations in network function from those associated with normal ageing. Here we elucidate the differential effects of ageing and Alzheimer's disease pathology through simultaneous analyses of two functional connectivity MRI datasets: (i) young participants harbouring highly-penetrant mutations leading to autosomal-dominant Alzheimer's disease from the Dominantly Inherited Alzheimer's Network (DIAN), an Alzheimer's disease cohort in which age-related comorbidities are minimal and likelihood of progression along an Alzheimer's disease trajectory is extremely high; and (ii) young and elderly participants from the Harvard Aging Brain Study, a cohort in which imaging biomarkers of amyloid burden and neurodegeneration can be used to disambiguate ageing alone from preclinical Alzheimer's disease. Consonant with prior reports, we observed the preferential degradation of cognitive (especially the default and dorsal attention networks) over motor and sensory networks in early autosomal-dominant Alzheimer's disease, and found that this distinctive degradation pattern was magnified in more advanced stages of disease. Importantly, a nascent form of the pattern observed across the autosomal-dominant Alzheimer's disease spectrum was also detectable in clinically normal elderly with clear biomarker evidence of Alzheimer's disease pathology (preclinical Alzheimer's disease). At the more granular level of individual connections between node pairs, we observed that connections within cognitive networks were preferentially targeted in Alzheimer's disease (with between network connections relatively spared), and that connections between positively coupled nodes (correlations) were preferentially degraded as compared to connections between negatively coupled nodes (anti-correlations). In contrast, ageing in the absence of Alzheimer's disease biomarkers was characterized by a far less network-specific degradation across cognitive and sensory networks, of between- and within-network connections, and of connections between positively and negatively coupled nodes. We go on to demonstrate that formalizing the differential patterns of network degradation in ageing and Alzheimer's disease may have the practical benefit of yielding connectivity measurements that highlight early Alzheimer's disease-related connectivity changes over those due to age-related processes. Together, the contrasting patterns of connectivity in Alzheimer's disease and ageing add to prior work arguing against Alzheimer's disease as a form of accelerated ageing, and suggest multi-network composite functional connectivity MRI metrics may be useful in the detection of early Alzheimer's disease-specific alterations co-occurring with age-related connectivity changes. More broadly, our findings are consistent with a specific pattern of network degradation associated with the spreading of Alzheimer's disease pathology within targeted neural networks.

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