Prefrontal cortex, negative symptoms, and schizophrenia

An MRI study

Cynthia G. Wible, Jane Anderson, Martha E. Shenton, Ashley Kricun, Yoshio Hirayasu, Shin Tanaka, James J. Levitt, Brian O'Donnell, Ron Kikinis, Ferenc A. Jolesz, Robert W. McCarley

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The present study measured prefrontal cortical gray and white matter volume in chronic, male schizophrenic subjects who were characterized by a higher proportion of mixed or negative symptoms than previous patients that we have evaluated. Seventeen chronic male schizophrenic subjects and 17 male control subjects were matched on age and handedness. Regions of interest (ROI) were measured using high-resolution magnetic resonance (MR) acquisitions consisting of contiguous 1.5-mm slices of the entire brain. No significant differences were found between schizophrenic and control subjects in mean values for prefrontal gray matter volume in either hemisphere. However, right prefrontal white matter was significantly reduced in the schizophrenic group. In addition, right prefrontal gray matter volume was significantly correlated with right hippocampal volume in the schizophrenic, but not in the control group. Furthermore, an analysis in which the current data were combined with those from a previous study showed that schizophrenic subjects with high negative symptom scores had significantly smaller bilateral white matter volumes than those with low negative symptom scores. White matter was significantly reduced in the right hemisphere in this group of schizophrenic subjects. Prefrontal volumes were also associated with negative symptom severity and with volumes of medial-temporal lobe regions - two results that were also found previously in schizophrenic subjects with mostly positive symptoms. These results underscore the importance of temporal-prefrontal pathways in the symptomatology of schizophrenia, and they suggest an association between prefrontal abnormalities and negative symptoms.

Original languageEnglish (US)
Pages (from-to)65-78
Number of pages14
JournalPsychiatry Research - Neuroimaging
Volume108
Issue number2
DOIs
StatePublished - Nov 30 2001
Externally publishedYes

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Prefrontal Cortex
Schizophrenia
Temporal Lobe
Functional Laterality
Magnetic Resonance Spectroscopy
Control Groups
White Matter
Brain
Gray Matter

Keywords

  • Hippocampus
  • Orbitofrontal cortex
  • Temporal lobe
  • White matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Wible, C. G., Anderson, J., Shenton, M. E., Kricun, A., Hirayasu, Y., Tanaka, S., ... McCarley, R. W. (2001). Prefrontal cortex, negative symptoms, and schizophrenia: An MRI study. Psychiatry Research - Neuroimaging, 108(2), 65-78. https://doi.org/10.1016/S0925-4927(01)00109-3

Prefrontal cortex, negative symptoms, and schizophrenia : An MRI study. / Wible, Cynthia G.; Anderson, Jane; Shenton, Martha E.; Kricun, Ashley; Hirayasu, Yoshio; Tanaka, Shin; Levitt, James J.; O'Donnell, Brian; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert W.

In: Psychiatry Research - Neuroimaging, Vol. 108, No. 2, 30.11.2001, p. 65-78.

Research output: Contribution to journalArticle

Wible, CG, Anderson, J, Shenton, ME, Kricun, A, Hirayasu, Y, Tanaka, S, Levitt, JJ, O'Donnell, B, Kikinis, R, Jolesz, FA & McCarley, RW 2001, 'Prefrontal cortex, negative symptoms, and schizophrenia: An MRI study', Psychiatry Research - Neuroimaging, vol. 108, no. 2, pp. 65-78. https://doi.org/10.1016/S0925-4927(01)00109-3
Wible CG, Anderson J, Shenton ME, Kricun A, Hirayasu Y, Tanaka S et al. Prefrontal cortex, negative symptoms, and schizophrenia: An MRI study. Psychiatry Research - Neuroimaging. 2001 Nov 30;108(2):65-78. https://doi.org/10.1016/S0925-4927(01)00109-3
Wible, Cynthia G. ; Anderson, Jane ; Shenton, Martha E. ; Kricun, Ashley ; Hirayasu, Yoshio ; Tanaka, Shin ; Levitt, James J. ; O'Donnell, Brian ; Kikinis, Ron ; Jolesz, Ferenc A. ; McCarley, Robert W. / Prefrontal cortex, negative symptoms, and schizophrenia : An MRI study. In: Psychiatry Research - Neuroimaging. 2001 ; Vol. 108, No. 2. pp. 65-78.
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