Pregenomic RNA is required for efficient incorporation of Pol polyprotein into foamy virus capsids

Martin Heinkelein, Cordula Leurs, Matthias Rammling, Katrin Peters, Helmut Hanenberg, Axel Rethwilm

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The foamy virus (FV) Pol polyprotein is translated independently of Gag from a spliced mRNA. This method of expression raises the question of how Pol is associated with the viral particle. Using a transient FV vector transfection system, it is shown that pregenomic RNA is required for efficient virion incorporation of functionally active Pol and that protein-protein interactions of Pol with Gag are not sufficient to complete particle assembly.

Original languageEnglish (US)
Pages (from-to)10069-10073
Number of pages5
JournalJournal of virology
Volume76
Issue number19
DOIs
StatePublished - Oct 2002

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Heinkelein, M., Leurs, C., Rammling, M., Peters, K., Hanenberg, H., & Rethwilm, A. (2002). Pregenomic RNA is required for efficient incorporation of Pol polyprotein into foamy virus capsids. Journal of virology, 76(19), 10069-10073. https://doi.org/10.1128/JVI.76.19.10069-10073.2002