Pregnancy as a Window to Future Cardiovascular Health: Design and Implementation of the nuMoM2b Heart Health Study

David Haas, Deborah B. Ehrenthal, Matthew A. Koch, Janet M. Catov, Shannon E. Barnes, Francesca Facco, Corette B. Parker, Brian M. Mercer, C. Noel Bairey-Merz, Robert M. Silver, Ronald J. Wapner, Hyagriv N. Simhan, Matthew K. Hoffman, William A. Grobman, Philip Greenland, Deborah A. Wing, George R. Saade, Samuel Parry, Phyllis C. Zee, Uma M. ReddyVictoria L. Pemberton, Dale R. Burwen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The National Institute of Child Health and Human Development's Nulliparous Pregnancy Outcomes Study-Monitoring Mothers-to-Be (nuMoM2b) Heart Health Study (HHS) was designed to investigate the relationships between adverse pregnancy outcomes and modifiable risk factors for cardiovascular disease. The ongoing nuMoM2b-HHS, which started in 2013, is a prospective follow-up of the nuMoM2b cohort, which included 10,038 women recruited between 2010 and 2013 from 8 centers across the United States who were initially observed over the course of their first pregnancies. In this report, we detail the design and study procedures of the nuMoM2b-HHS. Women in the pregnancy cohort who consented to be contacted for participation in future studies were approached at 6-month intervals to ascertain health information and to maintain ongoing contact. Two to 5 years after completion of the pregnancy documented in the nuMoM2b, women in the nuMoM2b-HHS were invited to an in-person study visit. During this visit, they completed psychosocial and medical history questionnaires and had clinical measurements and biological specimens obtained. A subcohort of participants who had objective assessments of sleep-disordered breathing during pregnancy were asked to repeat this investigation. This unique prospective observational study includes a large, geographically and ethnically diverse cohort, rich depth of phenotypic information about adverse pregnancy outcomes, and clinical data and biospecimens from early in the index pregnancy onward. Data obtained from this cohort will provide mechanistic and clinical insights into how data on a first pregnancy can provide information about the potential development of subsequent risk factors for cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)519-530
Number of pages12
JournalAmerican Journal of Epidemiology
Volume183
Issue number6
DOIs
StatePublished - Mar 15 2016

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Pregnancy
Health
Pregnancy Outcome
Cardiovascular Diseases
National Institute of Child Health and Human Development (U.S.)
Sleep Apnea Syndromes
Observational Studies
Mothers
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • cardiovascular disease
  • cohort study
  • heart health
  • methods
  • pregnancy
  • women's health

ASJC Scopus subject areas

  • Epidemiology

Cite this

Pregnancy as a Window to Future Cardiovascular Health : Design and Implementation of the nuMoM2b Heart Health Study. / Haas, David; Ehrenthal, Deborah B.; Koch, Matthew A.; Catov, Janet M.; Barnes, Shannon E.; Facco, Francesca; Parker, Corette B.; Mercer, Brian M.; Bairey-Merz, C. Noel; Silver, Robert M.; Wapner, Ronald J.; Simhan, Hyagriv N.; Hoffman, Matthew K.; Grobman, William A.; Greenland, Philip; Wing, Deborah A.; Saade, George R.; Parry, Samuel; Zee, Phyllis C.; Reddy, Uma M.; Pemberton, Victoria L.; Burwen, Dale R.

In: American Journal of Epidemiology, Vol. 183, No. 6, 15.03.2016, p. 519-530.

Research output: Contribution to journalArticle

Haas, D, Ehrenthal, DB, Koch, MA, Catov, JM, Barnes, SE, Facco, F, Parker, CB, Mercer, BM, Bairey-Merz, CN, Silver, RM, Wapner, RJ, Simhan, HN, Hoffman, MK, Grobman, WA, Greenland, P, Wing, DA, Saade, GR, Parry, S, Zee, PC, Reddy, UM, Pemberton, VL & Burwen, DR 2016, 'Pregnancy as a Window to Future Cardiovascular Health: Design and Implementation of the nuMoM2b Heart Health Study', American Journal of Epidemiology, vol. 183, no. 6, pp. 519-530. https://doi.org/10.1093/aje/kwv309
Haas, David ; Ehrenthal, Deborah B. ; Koch, Matthew A. ; Catov, Janet M. ; Barnes, Shannon E. ; Facco, Francesca ; Parker, Corette B. ; Mercer, Brian M. ; Bairey-Merz, C. Noel ; Silver, Robert M. ; Wapner, Ronald J. ; Simhan, Hyagriv N. ; Hoffman, Matthew K. ; Grobman, William A. ; Greenland, Philip ; Wing, Deborah A. ; Saade, George R. ; Parry, Samuel ; Zee, Phyllis C. ; Reddy, Uma M. ; Pemberton, Victoria L. ; Burwen, Dale R. / Pregnancy as a Window to Future Cardiovascular Health : Design and Implementation of the nuMoM2b Heart Health Study. In: American Journal of Epidemiology. 2016 ; Vol. 183, No. 6. pp. 519-530.
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