Preliminary effectiveness of breast cancer screening among 1.22 million Chinese females and different cancer patterns between urban and rural women

Yubei Huang, Hongji Dai, Fengju Song, Haixin Li, Ye Yan, Zhenhua Yang, Zhaoxiang Ye, Sheng Zhang, Hong Liu, Yali Cao, Li Xiong, Yahong Luo, Tie Pan, Xiangjun Ma, Jie Wang, Xiuling Song, Ling Leng, Yeping Zhang, Jie Sun, Jialin WangHengmin Ma, Lingzhi Kong, Zhenglong Lei, Yaogang Wang, Wang Peishan, Jiali Han, Xishan Hao, Kexin Chen

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12 Scopus citations

Abstract

To determine the preliminary effectiveness of breast cancer screening among Chinese females, 1226714 women aged 35-69 years first received clinical breast examinations. Urban women with suspected cancer received mammography followed by breast ultrasound (BUS), while rural suspected women underwent BUS followed by mammography. After one-year follow-up, 223 and 431 breast cancers were detected among urban and rural women (respectively), with overall detection rates of 0.56/1000 and 0.52/1000. Higher detection rates were significantly associated with older age at screening for both urban and rural women; additionally, urban women were at significantly higher risk if they had no job, no insurance, or were obese; additional risk factors specific to rural women included Han nationality, higher income, being unmarried, and having a family history of cancer (all P values < 0.05). Among screening-detected breast cancers in urban vs. rural women, 46.2% and 38.8% (respectively) were early stage, 62.5% and 66.3% were ≤2 centimeters, 38.0% and 47.3% included lymph-node involvement, and 14.0% and 6.0% were identified as carcinoma in situ. All abovementioned cancer characteristics were significantly better than clinic-detected cancers (all P values < 0.001). In conclusion, several important differences were found between urban and rural women in screening effectiveness and patterns of cancer distribution.

Original languageEnglish (US)
Article number39459
JournalScientific reports
Volume6
DOIs
StatePublished - Dec 20 2016

ASJC Scopus subject areas

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    Huang, Y., Dai, H., Song, F., Li, H., Yan, Y., Yang, Z., Ye, Z., Zhang, S., Liu, H., Cao, Y., Xiong, L., Luo, Y., Pan, T., Ma, X., Wang, J., Song, X., Leng, L., Zhang, Y., Sun, J., ... Chen, K. (2016). Preliminary effectiveness of breast cancer screening among 1.22 million Chinese females and different cancer patterns between urban and rural women. Scientific reports, 6, [39459]. https://doi.org/10.1038/srep39459