Preliminary observations on the effects of hyperbaric oxygen therapy on western diamondback rattlesnake (Crotalus atrox) venom poisoning in the rabbit model

Michael R. Stolpe, Robert L. Norris, Carey D. Chisholm, Michael F. Hartshorne, Carl Okerberg, William J. Ehler, John Posch

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Intermittent hyperbaric oxygen therapy has been shown to reduce skeletal muscle necrosis in a compartment syndrome animal model. To study whether intermittent exposure to hyperbaric oxygen augments antivenin therapy in reducing muscle necrosis, we injected sublethal doses of Western Diamondback rattlesnake (Crotalus atrox) venom intramuscularly into the hind legs of New Zealand White rabbits. In this pilot study, the animals were divided into three treatment groups. The first group received one vial of antivenin intravenously; the second group received one vial of antivenin intravenously plus three hyperbaric oxygen treatments; and the third group received no treatments. There were no statistically significant differences among the groups. These preliminary observations suggest that muscle necrosis secondary to Crotalus atrox venom poisoning is not significantly altered either by Antivenin [Crotalidae] Polyvalent at the dose level we used or in combination with intermittent hyperbaric oxygen treatments in this rabbit model.

Original languageEnglish (US)
Pages (from-to)871-874
Number of pages4
JournalAnnals of Emergency Medicine
Volume18
Issue number8
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Crotalus
Hyperbaric Oxygenation
Venoms
Antivenins
Poisoning
Rabbits
Necrosis
Oxygen
Therapeutics
Compartment Syndromes
Muscles
Leg
Skeletal Muscle
Animal Models

Keywords

  • hyperbaric oxygen therapy, snakebite
  • snakebite, hyperbaric oxygen therapy

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Preliminary observations on the effects of hyperbaric oxygen therapy on western diamondback rattlesnake (Crotalus atrox) venom poisoning in the rabbit model. / Stolpe, Michael R.; Norris, Robert L.; Chisholm, Carey D.; Hartshorne, Michael F.; Okerberg, Carl; Ehler, William J.; Posch, John.

In: Annals of Emergency Medicine, Vol. 18, No. 8, 1989, p. 871-874.

Research output: Contribution to journalArticle

Stolpe, Michael R. ; Norris, Robert L. ; Chisholm, Carey D. ; Hartshorne, Michael F. ; Okerberg, Carl ; Ehler, William J. ; Posch, John. / Preliminary observations on the effects of hyperbaric oxygen therapy on western diamondback rattlesnake (Crotalus atrox) venom poisoning in the rabbit model. In: Annals of Emergency Medicine. 1989 ; Vol. 18, No. 8. pp. 871-874.
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