Preliminary Report on Stone Breakage and Lesion Size Produced by a New Extracorporeal Electrohydraulic (Sparker Array) Discharge Device

Bret A. Connors, Ray B. Schaefer, John J. Gallagher, Cynthia D. Johnson, Guangyan Li, Rajash Handa, Andrew Evan

Research output: Contribution to journalArticle

Abstract

Objective: To determine if an innovative extracorporeal electrohydraulic shock wave (SW) device (sparker array [SPA]) can effectively fracture artificial stones in vitro and in vivo, and if SPA treatment produces a renal lesion in our pig model of lithotripsy injury. Results of these experiments will be used to help evaluate the suitability of this device as a clinical lithotripter. Materials and Methods: Ultracal-30 artificial stones were placed in a holder at the focus of the SPA and treated with 600 SWs (21.6 kV, 60 shocks/min). Stone fragments were collected, dried, and weighed to determine stone breakage. In vivo stone breakage entailed implanting stones into pigs. These stones were treated with 600 or 1200 SWs and the fragments were collected for analysis. Lesion analysis consisted of treating the left kidney of pigs with 1200 or 2400 SWs and quantitating the hemorrhagic lesion. Results: In vitro, 71% ± 2% of each artificial stone was fractured to <2 mm in size. In vivo stone breakage averaged 63%. Renal injury analysis revealed that only 1 of 7 kidneys showed evidence of hemorrhagic injury in the treated area. Conclusion: The SPA consistently comminuted artificial stones demonstrating its ability to fracture stones like other lithotripters. Also, the SPA caused little to no renal injury at the settings used in this study. These findings suggest further research is warranted to determine the potential of this device as a clinical lithotripter.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalUrology
Volume116
DOIs
StatePublished - Jun 1 2018

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Kidney
Equipment and Supplies
Swine
Wounds and Injuries
Lithotripsy
Shock
Research
In Vitro Techniques
Therapeutics

ASJC Scopus subject areas

  • Urology

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Preliminary Report on Stone Breakage and Lesion Size Produced by a New Extracorporeal Electrohydraulic (Sparker Array) Discharge Device. / Connors, Bret A.; Schaefer, Ray B.; Gallagher, John J.; Johnson, Cynthia D.; Li, Guangyan; Handa, Rajash; Evan, Andrew.

In: Urology, Vol. 116, 01.06.2018, p. 213-217.

Research output: Contribution to journalArticle

Connors, Bret A. ; Schaefer, Ray B. ; Gallagher, John J. ; Johnson, Cynthia D. ; Li, Guangyan ; Handa, Rajash ; Evan, Andrew. / Preliminary Report on Stone Breakage and Lesion Size Produced by a New Extracorporeal Electrohydraulic (Sparker Array) Discharge Device. In: Urology. 2018 ; Vol. 116. pp. 213-217.
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abstract = "Objective: To determine if an innovative extracorporeal electrohydraulic shock wave (SW) device (sparker array [SPA]) can effectively fracture artificial stones in vitro and in vivo, and if SPA treatment produces a renal lesion in our pig model of lithotripsy injury. Results of these experiments will be used to help evaluate the suitability of this device as a clinical lithotripter. Materials and Methods: Ultracal-30 artificial stones were placed in a holder at the focus of the SPA and treated with 600 SWs (21.6 kV, 60 shocks/min). Stone fragments were collected, dried, and weighed to determine stone breakage. In vivo stone breakage entailed implanting stones into pigs. These stones were treated with 600 or 1200 SWs and the fragments were collected for analysis. Lesion analysis consisted of treating the left kidney of pigs with 1200 or 2400 SWs and quantitating the hemorrhagic lesion. Results: In vitro, 71{\%} ± 2{\%} of each artificial stone was fractured to <2 mm in size. In vivo stone breakage averaged 63{\%}. Renal injury analysis revealed that only 1 of 7 kidneys showed evidence of hemorrhagic injury in the treated area. Conclusion: The SPA consistently comminuted artificial stones demonstrating its ability to fracture stones like other lithotripters. Also, the SPA caused little to no renal injury at the settings used in this study. These findings suggest further research is warranted to determine the potential of this device as a clinical lithotripter.",
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