Premature thelarche

Linda A. DiMeglio, Adda Grimberg

Research output: Chapter in Book/Report/Conference proceedingChapter


Premature thelache is the development of breast tissue prior to the normal age of pubertal onset. it can arise as a result of a number of different etiologies. This chapter provides an overview both of the physiology of normal breast development and of the causes of early thelarche, including benign self-limited premature thelarche, gonadotropin-independent precocious puberty, gonadotropin-dependent precocious puberty, exposure to exogenous estrogens, and non-hormonal mechanisms. A careful history and physical examination is essential is essential in order to determine the proper diagnostic approach. It is important for the clinican to differentiate benign premature thelarche from other causes that can have deleterious consequences, such as true precocious puberty.

Original languageEnglish (US)
Title of host publicationClinical Handbook of Insomnia
EditorsHrayr Attarian
Number of pages20
StatePublished - Dec 1 2010
Externally publishedYes

Publication series

NameCurrent Clinical Neurology
ISSN (Print)1559-0585


  • Breast morphogenesis
  • Ductal ectasia
  • Growth hormone
  • Neonatal gynecomastia
  • Ovarian cysts

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    DiMeglio, L. A., & Grimberg, A. (2010). Premature thelarche. In H. Attarian (Ed.), Clinical Handbook of Insomnia (pp. 169-188). (Current Clinical Neurology).