Prenatal inflammation exposure-programmed cardiovascular diseases and potential prevention

Youcai Deng, Liang Song, Xuqiang Nie, Weinian Shou, Xiaohui Li

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In recent years, the rapid development of medical and pharmacological interventions has led to a steady decline in certain noncommunicable chronic diseases (NCDs), such as cancer. However, the overall incidence of cardiovascular diseases (CVDs) has not seemed to decline. CVDs have become even more prevalent in many countries and represent a global health threat and financial burden. An increasing number of epidemiological and experimental studies have demonstrated that maternal insults not only can result in birth defects but also can cause developmental functional defects that contribute to adult NCDs. In the current review, we provide an overview of evidence from both epidemiological investigations and experimental animal studies supporting the concept of developmental reprogramming of adult CVDs in offspring that have experienced prenatal inflammation exposure (PIE) during fetal development (PIE-programmed CVDs), a disease-causing event that has not been effectively controlled. This review describes the epidemiological observations, data from animal models, and related mechanisms for the pathogenesis of PIE-programmed CVDs. In addition, the potential therapeutic interventions of PIE-programmed CVDs are discussed. Finally, we also deliberate the need for future mechanistic studies and biomarker screenings in this important field, which creates a great opportunity to combat the global increase in CVDs by managing the adverse effects of inflammation for prepregnant and pregnant individuals who are at risk for PIE-programmed CVDs.

Original languageEnglish (US)
JournalPharmacology and Therapeutics
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Cardiovascular Diseases
Inflammation
Chronic Disease
Fetal Development
Epidemiologic Studies
Animal Models
Biomarkers
Mothers
Pharmacology
Incidence
Neoplasms

Keywords

  • Cardiovascular diseases
  • developmental reprogramming
  • inflammation
  • maternal immune activation
  • NF-κB
  • prenatal inflammatory exposure

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Prenatal inflammation exposure-programmed cardiovascular diseases and potential prevention. / Deng, Youcai; Song, Liang; Nie, Xuqiang; Shou, Weinian; Li, Xiaohui.

In: Pharmacology and Therapeutics, 01.01.2018.

Research output: Contribution to journalArticle

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