Preosteoblast production in COSMOS 2044 rats: Short-term recovery of osteogenic potential

L. P. Garetto, E. R. Morey, G. N. Durnova, A. S. Kaplansky, W. E. Roberts

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The influence of a 13.8-day spaceflight and ~8.5-11 h of recovery at 1 g on fibroblast-like osteoblast precursor cells was assessed in the periodontal ligament of rat maxillary first molars. Preosteoblasts (C + D cells), less differentiated progenitor cells (A + A' cells), and nonosteogenic fibroblast- like cells (B cells) were identified by nuclear volume analysis (i.e., A + A' = 40-79 μm3; B = 80-119 μm3; C + D ≥ 120 μm3). No differences were observed among flight (F), synchronous (SC), vivarium, and basal control groups in the A + A' (F: 28.0 ± 3.7 vs. SC: 27.4 ± 2.2), B (F: 33.1 ± 1.4 vs. SC: 32.4 ± 2.4), or C + D (F: 38.4 ± 4.5 vs. SC: 39.2 ± 1.6) cell compartments (means ± SE, n = 5). Compared with previous spaceflight experiments, the present data are consistent with a postflight response to replenish preosteoblasts and restore periodontal ligament osteogenic potential. These data emphasize the need to 1) unequivocally determine the flight effect by killing the animals in-flight and 2) further assess the postflight recovery phenomenon.

Original languageEnglish (US)
Pages (from-to)14S-18S
JournalJournal of Applied Physiology
Volume73
Issue number2 SUPPL.
DOIs
StatePublished - 1992

Keywords

  • bone
  • cell differentiation
  • microgravity
  • osteogenesis
  • recovery
  • spaceflight

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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