Preschool multiple-breath washout testing an official American thoracic society technical statement

behalf of the ATS Assembly on Pediatrics

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial tree, although the extent to which this occurs can vary among conditions. The multiple-breath washout (MBW) test offers important insights into pediatric lung disease, not available through spirometry or resistance measurements. The European Respiratory Society/American Thoracic Society inert gas washout consensus statement led to the emergence of validated commercial equipment for the age group 6 years and above; specific recommendations for preschool children were beyond the scope of the document. Subsequently, the focus has shifted to MBW applications within preschool subjects (aged 2–6 yr), where a “window of opportunity” exists for early diagnosis of obstructive lung disease and intervention. Methods: This preschool-specific technical standards document was developed by an international group of experts, with expertise in both custom-built and commercial MBW equipment. A comprehensive review of published evidence was performed. Results: Recommendations were devised across areas that place specific age-related demands on MBW systems. Citing evidence where available in the literature, recommendations are made regarding procedures that should be used to achieve robust MBW results in the preschool age range. The present work also highlights the important unanswered questions that need to be addressed in future work. Conclusions: Consensus recommendations are outlined to direct interested groups of manufacturers, researchers, and clinicians in preschool device design, test performance, and data analysis for the MBW technique.

Original languageEnglish (US)
Pages (from-to)e1-e19
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume197
Issue number5
DOIs
StatePublished - Mar 1 2018

Fingerprint

Thorax
Equipment Design
Noble Gases
Obstructive Lung Diseases
Equipment and Supplies
Breath Tests
Spirometry
Preschool Children
Lung Diseases
Early Diagnosis
Age Groups
Research Personnel
Pediatrics

Keywords

  • Cystic fibrosis
  • Lung clearance index
  • Multiple-breath washout
  • Peripheral airway function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Preschool multiple-breath washout testing an official American thoracic society technical statement. / behalf of the ATS Assembly on Pediatrics.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 197, No. 5, 01.03.2018, p. e1-e19.

Research output: Contribution to journalArticle

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abstract = "Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial tree, although the extent to which this occurs can vary among conditions. The multiple-breath washout (MBW) test offers important insights into pediatric lung disease, not available through spirometry or resistance measurements. The European Respiratory Society/American Thoracic Society inert gas washout consensus statement led to the emergence of validated commercial equipment for the age group 6 years and above; specific recommendations for preschool children were beyond the scope of the document. Subsequently, the focus has shifted to MBW applications within preschool subjects (aged 2–6 yr), where a “window of opportunity” exists for early diagnosis of obstructive lung disease and intervention. Methods: This preschool-specific technical standards document was developed by an international group of experts, with expertise in both custom-built and commercial MBW equipment. A comprehensive review of published evidence was performed. Results: Recommendations were devised across areas that place specific age-related demands on MBW systems. Citing evidence where available in the literature, recommendations are made regarding procedures that should be used to achieve robust MBW results in the preschool age range. The present work also highlights the important unanswered questions that need to be addressed in future work. Conclusions: Consensus recommendations are outlined to direct interested groups of manufacturers, researchers, and clinicians in preschool device design, test performance, and data analysis for the MBW technique.",
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author = "{behalf of the ATS Assembly on Pediatrics} and Robinson, {Paul D.} and Philipp Latzin and Ramsey, {Kathryn A.} and Sanja Stanojevic and Paul Aurora and Stephanie Davis and Monika Gappa and Hall, {Graham L.} and Alex Horsley and Renee Jensen and Sooky Lum and Carlos Milla and Nielsen, {Kim G.} and Pittman, {Jessica E.} and Margaret Rosenfeld and Florian Singer and Padmaja Subbarao and Gustafsson, {Per M.} and Felix Ratjen",
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T1 - Preschool multiple-breath washout testing an official American thoracic society technical statement

AU - behalf of the ATS Assembly on Pediatrics

AU - Robinson, Paul D.

AU - Latzin, Philipp

AU - Ramsey, Kathryn A.

AU - Stanojevic, Sanja

AU - Aurora, Paul

AU - Davis, Stephanie

AU - Gappa, Monika

AU - Hall, Graham L.

AU - Horsley, Alex

AU - Jensen, Renee

AU - Lum, Sooky

AU - Milla, Carlos

AU - Nielsen, Kim G.

AU - Pittman, Jessica E.

AU - Rosenfeld, Margaret

AU - Singer, Florian

AU - Subbarao, Padmaja

AU - Gustafsson, Per M.

AU - Ratjen, Felix

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N2 - Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial tree, although the extent to which this occurs can vary among conditions. The multiple-breath washout (MBW) test offers important insights into pediatric lung disease, not available through spirometry or resistance measurements. The European Respiratory Society/American Thoracic Society inert gas washout consensus statement led to the emergence of validated commercial equipment for the age group 6 years and above; specific recommendations for preschool children were beyond the scope of the document. Subsequently, the focus has shifted to MBW applications within preschool subjects (aged 2–6 yr), where a “window of opportunity” exists for early diagnosis of obstructive lung disease and intervention. Methods: This preschool-specific technical standards document was developed by an international group of experts, with expertise in both custom-built and commercial MBW equipment. A comprehensive review of published evidence was performed. Results: Recommendations were devised across areas that place specific age-related demands on MBW systems. Citing evidence where available in the literature, recommendations are made regarding procedures that should be used to achieve robust MBW results in the preschool age range. The present work also highlights the important unanswered questions that need to be addressed in future work. Conclusions: Consensus recommendations are outlined to direct interested groups of manufacturers, researchers, and clinicians in preschool device design, test performance, and data analysis for the MBW technique.

AB - Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial tree, although the extent to which this occurs can vary among conditions. The multiple-breath washout (MBW) test offers important insights into pediatric lung disease, not available through spirometry or resistance measurements. The European Respiratory Society/American Thoracic Society inert gas washout consensus statement led to the emergence of validated commercial equipment for the age group 6 years and above; specific recommendations for preschool children were beyond the scope of the document. Subsequently, the focus has shifted to MBW applications within preschool subjects (aged 2–6 yr), where a “window of opportunity” exists for early diagnosis of obstructive lung disease and intervention. Methods: This preschool-specific technical standards document was developed by an international group of experts, with expertise in both custom-built and commercial MBW equipment. A comprehensive review of published evidence was performed. Results: Recommendations were devised across areas that place specific age-related demands on MBW systems. Citing evidence where available in the literature, recommendations are made regarding procedures that should be used to achieve robust MBW results in the preschool age range. The present work also highlights the important unanswered questions that need to be addressed in future work. Conclusions: Consensus recommendations are outlined to direct interested groups of manufacturers, researchers, and clinicians in preschool device design, test performance, and data analysis for the MBW technique.

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KW - Multiple-breath washout

KW - Peripheral airway function

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