Preschoolers are not miniature adolescents: A comparison of insulin pump doses in two groups of children with type 1 diabetes mellitus

Linda DiMeglio, Sheryl R. Boyd, Tina M. Pottorff, Jennifer L. Cleveland, Naomi Fineberg, Erica Eugster

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We analyzed glycemic control and insulin usage patterns of 14 preschoolers and 14 adolescents on continuous subcutaneous insulin infusion (CSII) matched for sex to determine how CSII therapy for type 1 diabetes mellitus (DM1) differs in preschoolers as compared to adolescents. Average hemoglobin A1c was lower in the adolescents. The percent of insulin delivered as the basal rate was the same in both groups; however, during the hours after midnight the preschoolers needed a much lower basal rate per kg body weight. There were also significant differences in insulin sensitivity and insulin/carbohydrate ratios. The number of basal rates, number of boluses, and percent of insulin administered as the basal rate were not different between groups. This is the first report of discrete differences in insulin usage patterns for preschoolers and adolescents on insulin pumps. Reasons for these dissimilarities include differences in hormone production, insulin absorption, frequency of food intake, and glycemic targets. Recognizing these variations is essential for safe and efficacious use of CSII in preschoolers with DM1.

Original languageEnglish
Pages (from-to)865-870
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume17
Issue number6
StatePublished - 2004

Fingerprint

Type 1 Diabetes Mellitus
Insulin
Subcutaneous Infusions
Insulin Resistance
Hemoglobins
Eating
Body Weight
Carbohydrates
Hormones

Keywords

  • Continuous subcutaneous insulin infusion
  • Dose
  • Insulin pump
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

Preschoolers are not miniature adolescents : A comparison of insulin pump doses in two groups of children with type 1 diabetes mellitus. / DiMeglio, Linda; Boyd, Sheryl R.; Pottorff, Tina M.; Cleveland, Jennifer L.; Fineberg, Naomi; Eugster, Erica.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 17, No. 6, 2004, p. 865-870.

Research output: Contribution to journalArticle

@article{73176503e12b491183d07fb24db8dccf,
title = "Preschoolers are not miniature adolescents: A comparison of insulin pump doses in two groups of children with type 1 diabetes mellitus",
abstract = "We analyzed glycemic control and insulin usage patterns of 14 preschoolers and 14 adolescents on continuous subcutaneous insulin infusion (CSII) matched for sex to determine how CSII therapy for type 1 diabetes mellitus (DM1) differs in preschoolers as compared to adolescents. Average hemoglobin A1c was lower in the adolescents. The percent of insulin delivered as the basal rate was the same in both groups; however, during the hours after midnight the preschoolers needed a much lower basal rate per kg body weight. There were also significant differences in insulin sensitivity and insulin/carbohydrate ratios. The number of basal rates, number of boluses, and percent of insulin administered as the basal rate were not different between groups. This is the first report of discrete differences in insulin usage patterns for preschoolers and adolescents on insulin pumps. Reasons for these dissimilarities include differences in hormone production, insulin absorption, frequency of food intake, and glycemic targets. Recognizing these variations is essential for safe and efficacious use of CSII in preschoolers with DM1.",
keywords = "Continuous subcutaneous insulin infusion, Dose, Insulin pump, Type 1 diabetes mellitus",
author = "Linda DiMeglio and Boyd, {Sheryl R.} and Pottorff, {Tina M.} and Cleveland, {Jennifer L.} and Naomi Fineberg and Erica Eugster",
year = "2004",
language = "English",
volume = "17",
pages = "865--870",
journal = "Journal of Pediatric Endocrinology and Metabolism",
issn = "0334-018X",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "6",

}

TY - JOUR

T1 - Preschoolers are not miniature adolescents

T2 - A comparison of insulin pump doses in two groups of children with type 1 diabetes mellitus

AU - DiMeglio, Linda

AU - Boyd, Sheryl R.

AU - Pottorff, Tina M.

AU - Cleveland, Jennifer L.

AU - Fineberg, Naomi

AU - Eugster, Erica

PY - 2004

Y1 - 2004

N2 - We analyzed glycemic control and insulin usage patterns of 14 preschoolers and 14 adolescents on continuous subcutaneous insulin infusion (CSII) matched for sex to determine how CSII therapy for type 1 diabetes mellitus (DM1) differs in preschoolers as compared to adolescents. Average hemoglobin A1c was lower in the adolescents. The percent of insulin delivered as the basal rate was the same in both groups; however, during the hours after midnight the preschoolers needed a much lower basal rate per kg body weight. There were also significant differences in insulin sensitivity and insulin/carbohydrate ratios. The number of basal rates, number of boluses, and percent of insulin administered as the basal rate were not different between groups. This is the first report of discrete differences in insulin usage patterns for preschoolers and adolescents on insulin pumps. Reasons for these dissimilarities include differences in hormone production, insulin absorption, frequency of food intake, and glycemic targets. Recognizing these variations is essential for safe and efficacious use of CSII in preschoolers with DM1.

AB - We analyzed glycemic control and insulin usage patterns of 14 preschoolers and 14 adolescents on continuous subcutaneous insulin infusion (CSII) matched for sex to determine how CSII therapy for type 1 diabetes mellitus (DM1) differs in preschoolers as compared to adolescents. Average hemoglobin A1c was lower in the adolescents. The percent of insulin delivered as the basal rate was the same in both groups; however, during the hours after midnight the preschoolers needed a much lower basal rate per kg body weight. There were also significant differences in insulin sensitivity and insulin/carbohydrate ratios. The number of basal rates, number of boluses, and percent of insulin administered as the basal rate were not different between groups. This is the first report of discrete differences in insulin usage patterns for preschoolers and adolescents on insulin pumps. Reasons for these dissimilarities include differences in hormone production, insulin absorption, frequency of food intake, and glycemic targets. Recognizing these variations is essential for safe and efficacious use of CSII in preschoolers with DM1.

KW - Continuous subcutaneous insulin infusion

KW - Dose

KW - Insulin pump

KW - Type 1 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=3242892869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242892869&partnerID=8YFLogxK

M3 - Article

C2 - 15270404

AN - SCOPUS:3242892869

VL - 17

SP - 865

EP - 870

JO - Journal of Pediatric Endocrinology and Metabolism

JF - Journal of Pediatric Endocrinology and Metabolism

SN - 0334-018X

IS - 6

ER -