Presence of concomitant inflammatory bowel disease is associated with an increased risk of postcholecystectomy complications

Udayakumar Navaneethan, Anuja Choure, Preethi G.K. Venkatesh, Jeffrey Hammel, Jingmei Lin, John R. Goldblum, Elena Manilich, Ravi P. Kiran, Feza H. Remzi, Bo Shen

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Surgery in patients with inflammatory bowel disease (IBD) is often associated with complications. The aim of our study was to evaluate whether concomitant IBD was associated with an increased risk of postcholecystectomy complications. Methods: The study group consisted of 82 consecutive IBD patients who underwent cholecystectomy from January 2001 to October 2010. The control group included 296 cholecystectomy patients without IBD who were randomly selected from the cholecystectomy database. Variables were analyzed by univariate and multivariate analyses. Results: There were no significant differences in age, gender, body mass index, presence of gallstones/common bile duct stones, indication for cholecystectomy, and postoperative mortality between the study and control groups. More patients in the study group had postoperative complications than in the control group (17.1% vs. 6.8%, P = 0.005). On multivariate analysis, the presence of concomitant IBD was independently associated with an increased risk for postoperative complications (odds ratio [OR] = 4.64; 95% confidence interval [CI], 1.63-13.20, P = 0.004) after adjusting for age, the presence of cirrhosis, diabetes, body mass index, the use of corticosteroids, immunomodulators, total parental nutrition, or biologics, the presence of primary sclerosing cholangitis (PSC), acute or chronic cholecystitis, cholelithiasis, or prior abdominal surgeries, and indication for surgery (elective vs. emergent). Conclusions: IBD patients undergoing cholecystectomy have a significantly increased risk of postoperative complications. Although further studies are warranted to clarify the reason for these differences, caution should be taken to determine the need and timing of cholecystectomy in IBD patients.

Original languageEnglish (US)
Pages (from-to)1682-1688
Number of pages7
JournalInflammatory bowel diseases
Volume18
Issue number9
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Keywords

  • cholecystectomy
  • complications
  • inflammatory bowel diseases
  • primary sclerosing cholangitis
  • ulcerative colitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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    Navaneethan, U., Choure, A., Venkatesh, P. G. K., Hammel, J., Lin, J., Goldblum, J. R., Manilich, E., Kiran, R. P., Remzi, F. H., & Shen, B. (2012). Presence of concomitant inflammatory bowel disease is associated with an increased risk of postcholecystectomy complications. Inflammatory bowel diseases, 18(9), 1682-1688. https://doi.org/10.1002/ibd.21917