Presentation of hypoparathyroidism

Etiologies and clinical features

Dolores M. Shoback, John P. Bilezikian, Aline G. Costa, David Dempster, Henning Dralle, Aliya A. Khan, Munro Peacock, Marco Raffaelli, Barbara C. Silva, Rajesh V. Thakker, Tamara Vokes, Roger Bouillon

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Context: Understanding the etiology, diagnosis, and symptoms of hypoparathyroidism may help to improve quality of life and long-term disease outcomes. This paper summarizes the results of the findings and recommendations of the Working Group on Presentation of Hypoparathyroidism. Evidence Acquisition: Expertsconvenedin Florence, Italy, inMay2015andevaluated the literatureand recent data on the presentation and long-term outcomes of patients with hypoparathyroidism. Evidence Synthesis: The most frequent etiology is surgical removal or loss of viability of parathyroid glands. Despite precautions and expertise, about 20-30% of patients develop transient and 1-7% developpermanentpostsurgicalhypoparathyroidismafter totalthyroidectomy.Autoimmunedestruction is the main reason for nonsurgical hypoparathyroidism. Severe magnesium deficiency is an uncommon but correctable cause of hypoparathyroidism. Several genetic etiologies can result in the loss of parathyroid function or action causing isolated hypoparathyroidism or a complex syndrome with other symptoms apart from those of hypoparathyroidism or pseudohypoparathyroidism. Neuromuscular signs or symptoms due to hypocalcemia are the main characteristics of the disease. Hyperphosphatemia can contribute to major long-term complications such as ectopic calcifications in the kidney, brain, eye, or vasculature. Bone turnover is decreased, and bone mass is increased. Reduced quality of life and higher risk of renal stones, renal calcifications, and renal failure are seen. The risk of seizures and silent or symptomatic calcifications of basal ganglia is also increased. Conclusions: Increased awareness of the etiologyandpresentation of the diseaseandnewresearch efforts addressing specific questions formulated during the meeting should improve the diagnosis, care, and long-term outcome for patients.

Original languageEnglish (US)
Pages (from-to)2300-2312
Number of pages13
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number6
DOIs
StatePublished - Jun 1 2016

Fingerprint

Hypoparathyroidism
Bone
Magnesium
Brain
Kidney
Neuromuscular Manifestations
Quality of Life
Pseudohypoparathyroidism
Magnesium Deficiency
Hyperphosphatemia
Parathyroid Glands
Hypocalcemia
Bone Remodeling
Long-Term Care
Basal Ganglia
Italy
Renal Insufficiency
Seizures
Bone and Bones

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Shoback, D. M., Bilezikian, J. P., Costa, A. G., Dempster, D., Dralle, H., Khan, A. A., ... Bouillon, R. (2016). Presentation of hypoparathyroidism: Etiologies and clinical features. Journal of Clinical Endocrinology and Metabolism, 101(6), 2300-2312. https://doi.org/10.1210/jc.2015-3909

Presentation of hypoparathyroidism : Etiologies and clinical features. / Shoback, Dolores M.; Bilezikian, John P.; Costa, Aline G.; Dempster, David; Dralle, Henning; Khan, Aliya A.; Peacock, Munro; Raffaelli, Marco; Silva, Barbara C.; Thakker, Rajesh V.; Vokes, Tamara; Bouillon, Roger.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 101, No. 6, 01.06.2016, p. 2300-2312.

Research output: Contribution to journalArticle

Shoback, DM, Bilezikian, JP, Costa, AG, Dempster, D, Dralle, H, Khan, AA, Peacock, M, Raffaelli, M, Silva, BC, Thakker, RV, Vokes, T & Bouillon, R 2016, 'Presentation of hypoparathyroidism: Etiologies and clinical features', Journal of Clinical Endocrinology and Metabolism, vol. 101, no. 6, pp. 2300-2312. https://doi.org/10.1210/jc.2015-3909
Shoback DM, Bilezikian JP, Costa AG, Dempster D, Dralle H, Khan AA et al. Presentation of hypoparathyroidism: Etiologies and clinical features. Journal of Clinical Endocrinology and Metabolism. 2016 Jun 1;101(6):2300-2312. https://doi.org/10.1210/jc.2015-3909
Shoback, Dolores M. ; Bilezikian, John P. ; Costa, Aline G. ; Dempster, David ; Dralle, Henning ; Khan, Aliya A. ; Peacock, Munro ; Raffaelli, Marco ; Silva, Barbara C. ; Thakker, Rajesh V. ; Vokes, Tamara ; Bouillon, Roger. / Presentation of hypoparathyroidism : Etiologies and clinical features. In: Journal of Clinical Endocrinology and Metabolism. 2016 ; Vol. 101, No. 6. pp. 2300-2312.
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