Presentation of multicentric Castleman's disease with sicca syndrome, cardiomyopathy, palmar and plantar rash

S. F. Kingsmore, O. E. Silva, B. D. Hall, E. A. Sheldon, L. D. Cripe, E. W. St. Clair

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Multicentric Castleman's disease (MCD), or multicentric angiofollicular lymph node hyperplasia, is an uncommon lymphoproliferative disorder which typically presents with constitutional symptoms, multicentric lymphadenopathy, hepatosplenomegaly, effusions, and ascites. We describe a patient with several novel manifestations of MCD: sicca syndrome, lacrimal and salivary gland enlargement, cardiomyopathy, and palmar and plantar rash. Treatment of MCD with chlorambucil and prednisone was effective in the short term followup of this patient. MCD merits consideration in patients with lymphadenopathy and multisystem disease, including sicca syndrome, heart failure or rash.

Original languageEnglish (US)
Pages (from-to)1588-1591
Number of pages4
JournalJournal of Rheumatology
Volume20
Issue number9
StatePublished - Dec 1 1993
Externally publishedYes

Keywords

  • CARDIOMYOPATHY
  • LYMPHADENOPATHY
  • MULTICENTRIC CASTLEMAN'S DISEASE
  • SICCA SYNDROME

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Kingsmore, S. F., Silva, O. E., Hall, B. D., Sheldon, E. A., Cripe, L. D., & St. Clair, E. W. (1993). Presentation of multicentric Castleman's disease with sicca syndrome, cardiomyopathy, palmar and plantar rash. Journal of Rheumatology, 20(9), 1588-1591.