Preservation of cognitive function with antihypertensive medications

A longitudinal analysis of a community-based sample of African Americans

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Background: Results of previous studies of white older adults suggest that antihypertensive medications preserve cognition. We assessed the long-term effect of antihypertensive medications on cognitive function in a community sample of African American older adults. Methods: We conducted longitudinal surveys and clinical assessment of cognitive function in a random sample of 2212 community-dwelling African Americans 65 years and older. We identified 1900 participants without evidence of cognitive impairment at baseline, 1617 of whom had subsequent follow-up information, and 946 of whom had blood pressure measurements. Cognitive function was measured at baseline and at 2 and 5 years by means of scores on the Community Screening Instrument for Dementia and neuropsychological and clinical assessment for dementia and cognitive impairment. Prescription and nonprescription medication use was derived from in-home inspection of medications and participant and informant reports. Results: Of 1900 participants, 288 (15.2%) developed incident cognitive impairment. Using logistic regression to control for the effects of age, sex, education, baseline cognitive scores, and hypertension and angina or myocardial infarction, we found that antihypertensive medications reduced the odds of incident cognitive impairment by 38% (odds ratio, 0.62; 95% confidence interval, 0.45-0.84). Corresponding analysis using blood pressure measurements on the subset of participants was inconclusive. Conclusion: Antihypertensive medication use is associated with preservation of cognitive function in older African American adults.

Original languageEnglish
Pages (from-to)2090-2096
Number of pages7
JournalArchives of Internal Medicine
Volume162
Issue number18
DOIs
StatePublished - Oct 14 2002

Fingerprint

African Americans
Cognition
Antihypertensive Agents
Dementia
Blood Pressure
Independent Living
Sex Education
Prescriptions
Longitudinal Studies
Logistic Models
Odds Ratio
Myocardial Infarction
Confidence Intervals
Hypertension
Cognitive Dysfunction

ASJC Scopus subject areas

  • Internal Medicine

Cite this

@article{de5b6f31425f4648aa36877dff5bbef3,
title = "Preservation of cognitive function with antihypertensive medications: A longitudinal analysis of a community-based sample of African Americans",
abstract = "Background: Results of previous studies of white older adults suggest that antihypertensive medications preserve cognition. We assessed the long-term effect of antihypertensive medications on cognitive function in a community sample of African American older adults. Methods: We conducted longitudinal surveys and clinical assessment of cognitive function in a random sample of 2212 community-dwelling African Americans 65 years and older. We identified 1900 participants without evidence of cognitive impairment at baseline, 1617 of whom had subsequent follow-up information, and 946 of whom had blood pressure measurements. Cognitive function was measured at baseline and at 2 and 5 years by means of scores on the Community Screening Instrument for Dementia and neuropsychological and clinical assessment for dementia and cognitive impairment. Prescription and nonprescription medication use was derived from in-home inspection of medications and participant and informant reports. Results: Of 1900 participants, 288 (15.2{\%}) developed incident cognitive impairment. Using logistic regression to control for the effects of age, sex, education, baseline cognitive scores, and hypertension and angina or myocardial infarction, we found that antihypertensive medications reduced the odds of incident cognitive impairment by 38{\%} (odds ratio, 0.62; 95{\%} confidence interval, 0.45-0.84). Corresponding analysis using blood pressure measurements on the subset of participants was inconclusive. Conclusion: Antihypertensive medication use is associated with preservation of cognitive function in older African American adults.",
author = "Michael Murray and Lane, {Kathleen A.} and Sujuan Gao and Evans, {Rebecca M.} and Frederick Unverzagt and Kathleen Hall and Hugh Hendrie",
year = "2002",
month = "10",
day = "14",
doi = "10.1001/archinte.162.18.2090",
language = "English",
volume = "162",
pages = "2090--2096",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "18",

}

TY - JOUR

T1 - Preservation of cognitive function with antihypertensive medications

T2 - A longitudinal analysis of a community-based sample of African Americans

AU - Murray, Michael

AU - Lane, Kathleen A.

AU - Gao, Sujuan

AU - Evans, Rebecca M.

AU - Unverzagt, Frederick

AU - Hall, Kathleen

AU - Hendrie, Hugh

PY - 2002/10/14

Y1 - 2002/10/14

N2 - Background: Results of previous studies of white older adults suggest that antihypertensive medications preserve cognition. We assessed the long-term effect of antihypertensive medications on cognitive function in a community sample of African American older adults. Methods: We conducted longitudinal surveys and clinical assessment of cognitive function in a random sample of 2212 community-dwelling African Americans 65 years and older. We identified 1900 participants without evidence of cognitive impairment at baseline, 1617 of whom had subsequent follow-up information, and 946 of whom had blood pressure measurements. Cognitive function was measured at baseline and at 2 and 5 years by means of scores on the Community Screening Instrument for Dementia and neuropsychological and clinical assessment for dementia and cognitive impairment. Prescription and nonprescription medication use was derived from in-home inspection of medications and participant and informant reports. Results: Of 1900 participants, 288 (15.2%) developed incident cognitive impairment. Using logistic regression to control for the effects of age, sex, education, baseline cognitive scores, and hypertension and angina or myocardial infarction, we found that antihypertensive medications reduced the odds of incident cognitive impairment by 38% (odds ratio, 0.62; 95% confidence interval, 0.45-0.84). Corresponding analysis using blood pressure measurements on the subset of participants was inconclusive. Conclusion: Antihypertensive medication use is associated with preservation of cognitive function in older African American adults.

AB - Background: Results of previous studies of white older adults suggest that antihypertensive medications preserve cognition. We assessed the long-term effect of antihypertensive medications on cognitive function in a community sample of African American older adults. Methods: We conducted longitudinal surveys and clinical assessment of cognitive function in a random sample of 2212 community-dwelling African Americans 65 years and older. We identified 1900 participants without evidence of cognitive impairment at baseline, 1617 of whom had subsequent follow-up information, and 946 of whom had blood pressure measurements. Cognitive function was measured at baseline and at 2 and 5 years by means of scores on the Community Screening Instrument for Dementia and neuropsychological and clinical assessment for dementia and cognitive impairment. Prescription and nonprescription medication use was derived from in-home inspection of medications and participant and informant reports. Results: Of 1900 participants, 288 (15.2%) developed incident cognitive impairment. Using logistic regression to control for the effects of age, sex, education, baseline cognitive scores, and hypertension and angina or myocardial infarction, we found that antihypertensive medications reduced the odds of incident cognitive impairment by 38% (odds ratio, 0.62; 95% confidence interval, 0.45-0.84). Corresponding analysis using blood pressure measurements on the subset of participants was inconclusive. Conclusion: Antihypertensive medication use is associated with preservation of cognitive function in older African American adults.

UR - http://www.scopus.com/inward/record.url?scp=0037078284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037078284&partnerID=8YFLogxK

U2 - 10.1001/archinte.162.18.2090

DO - 10.1001/archinte.162.18.2090

M3 - Article

VL - 162

SP - 2090

EP - 2096

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 18

ER -