Preservation of postprandial intestinal hyperemic response after small bowl transplantation

Rong Yang, Qui Liu, Joseph L. Unthank, Mark D. Pescovitz, Jay L. Grosfeld

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Postprandial intestinal hyperemia (PIH) is a normal physiological phenomenon and is thought to accommodate the increased intestinal metabolic demand during food digestion. Lack of such a response could lead to malabsorption. The purpose of this study was to determine whether transplanted intestine retains the ability to mediate PIH. Nineteen rats with syngeneic orthotopic small bowel transplantation (SBT) and 13 normal controls were further divided into two subgroups to receive gastric gavage of either 2 mL of Ensure Plus (EP) high-calorie liquid nutrition or 2 mL of normal saline. Intestinal blood flow was determined before, and 20 and 45 minutes after the gavage, employing a colored microsphere technique. The results showed that basal blood flow to the transplanted intestine (56.7 ± 26.7 mL/min/100 g) was similar to that of normal intestine (64.2 ± 35.8 mL/min/100 g; P > .1). EP feeding elicited a marked increase in intestinal blood flow (PIH phenomenon) in both normal and SBT animals. The magnitudes of flow increase were similar for the two groups (249 ± 99% versus 241 ± 76% of baseline 45 minutes after EP feeding in the normal and transplanted intestine, respectively; P > .1). The results indicate that hyperemic response to feeding is normal in syngeneic orthotopic SBT.

Original languageEnglish (US)
Pages (from-to)1090-1092
Number of pages3
JournalJournal of pediatric surgery
Volume30
Issue number7
DOIs
StatePublished - Jul 1995

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Keywords

  • intestinal blood flow
  • postprandial intestinal hyperemia
  • Small bowel transplantation

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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