Preserved forearm endothelial responses with acute exposure to progesterone: A randomized cross-over trial of 17-β estradiol, progesterone, and 17-β estradiol with progesterone in healthy menopausal women

Kieren Mather, Eric G. Norman, Jerilynn C. Prior, Thomas G. Elliott

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27 Citations (Scopus)

Abstract

Regularly menstruating women are relatively protected from cardiovascular disease. Epidemiological and endothelial function studies attribute this protection to estradiol (E2), but both progesterone (P) and E2 are normally present. A range of vascular effects of added progestins have been described, from neutral to detrimental, but the effects of P per se on endothelial function in humans have not been reported. We therefore investigated the acute effects of E2, P, and E2 combined with P, on endothelium-dependent and -independent forearm blood flow responses. Using venous occlusion plethysmography, forearm blood flow (FBF) was measured during acute brachial artery infusions, achieving physiologic levels of 17-β-E2, P, and 17-β-E2 with P in healthy menopausal women with no cardiovascular disease risk factors. Vehicle or hormones were infused, in random order, on 4 days, 1 week apart. Flow responses were measured during coinfusions of hormone with the endothelium-dependent vasodilator acetylcholine and the endothelium-independent vasodilator sodium nitroprusside. Twenty-seven healthy menopausal women were studied, and all had normal baseline endothelial responses. Small (∼15%), statistically nonsignificant increases in endothelium-dependent flow responses were seen after all acute hormone treatments. No impairment in response was seen with P alone or in combination with 17-β-E2. In healthy menopausal women without cardiovascular disease risk factors and without baseline defects in endothelial function, acute exposure to physiologic levels of 17-β-E2, P, and 17-β-E2 with P produced equivalent endothelium-dependent responses. These data suggest that P does not have detrimental vascular effects in humans.

Original languageEnglish
Pages (from-to)4644-4649
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume85
Issue number12
DOIs
StatePublished - 2000

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Forearm
Cross-Over Studies
Endothelium
Progesterone
Estradiol
Hormones
Cardiovascular Diseases
Blood
Plethysmography
Blood Vessels
Endothelium-Dependent Relaxing Factors
Nitroprusside
Progestins
Vasodilator Agents
Acetylcholine
Brachial Artery
Defects
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Preserved forearm endothelial responses with acute exposure to progesterone: A randomized cross-over trial of 17-β estradiol, progesterone, and 17-β estradiol with progesterone in healthy menopausal women",
abstract = "Regularly menstruating women are relatively protected from cardiovascular disease. Epidemiological and endothelial function studies attribute this protection to estradiol (E2), but both progesterone (P) and E2 are normally present. A range of vascular effects of added progestins have been described, from neutral to detrimental, but the effects of P per se on endothelial function in humans have not been reported. We therefore investigated the acute effects of E2, P, and E2 combined with P, on endothelium-dependent and -independent forearm blood flow responses. Using venous occlusion plethysmography, forearm blood flow (FBF) was measured during acute brachial artery infusions, achieving physiologic levels of 17-β-E2, P, and 17-β-E2 with P in healthy menopausal women with no cardiovascular disease risk factors. Vehicle or hormones were infused, in random order, on 4 days, 1 week apart. Flow responses were measured during coinfusions of hormone with the endothelium-dependent vasodilator acetylcholine and the endothelium-independent vasodilator sodium nitroprusside. Twenty-seven healthy menopausal women were studied, and all had normal baseline endothelial responses. Small (∼15{\%}), statistically nonsignificant increases in endothelium-dependent flow responses were seen after all acute hormone treatments. No impairment in response was seen with P alone or in combination with 17-β-E2. In healthy menopausal women without cardiovascular disease risk factors and without baseline defects in endothelial function, acute exposure to physiologic levels of 17-β-E2, P, and 17-β-E2 with P produced equivalent endothelium-dependent responses. These data suggest that P does not have detrimental vascular effects in humans.",
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T1 - Preserved forearm endothelial responses with acute exposure to progesterone

T2 - A randomized cross-over trial of 17-β estradiol, progesterone, and 17-β estradiol with progesterone in healthy menopausal women

AU - Mather, Kieren

AU - Norman, Eric G.

AU - Prior, Jerilynn C.

AU - Elliott, Thomas G.

PY - 2000

Y1 - 2000

N2 - Regularly menstruating women are relatively protected from cardiovascular disease. Epidemiological and endothelial function studies attribute this protection to estradiol (E2), but both progesterone (P) and E2 are normally present. A range of vascular effects of added progestins have been described, from neutral to detrimental, but the effects of P per se on endothelial function in humans have not been reported. We therefore investigated the acute effects of E2, P, and E2 combined with P, on endothelium-dependent and -independent forearm blood flow responses. Using venous occlusion plethysmography, forearm blood flow (FBF) was measured during acute brachial artery infusions, achieving physiologic levels of 17-β-E2, P, and 17-β-E2 with P in healthy menopausal women with no cardiovascular disease risk factors. Vehicle or hormones were infused, in random order, on 4 days, 1 week apart. Flow responses were measured during coinfusions of hormone with the endothelium-dependent vasodilator acetylcholine and the endothelium-independent vasodilator sodium nitroprusside. Twenty-seven healthy menopausal women were studied, and all had normal baseline endothelial responses. Small (∼15%), statistically nonsignificant increases in endothelium-dependent flow responses were seen after all acute hormone treatments. No impairment in response was seen with P alone or in combination with 17-β-E2. In healthy menopausal women without cardiovascular disease risk factors and without baseline defects in endothelial function, acute exposure to physiologic levels of 17-β-E2, P, and 17-β-E2 with P produced equivalent endothelium-dependent responses. These data suggest that P does not have detrimental vascular effects in humans.

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