Preshock phase singularity and the outcome of ventricular defibrillation

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Phase singularity (PS) is a topological defect that serves as a source of ventricular fibrillation (VF). Whether or not the quantity of preshock PS determines defibrillation outcome is unclear. Objective: The purpose of this study was to test the hypothesis that the number of PSs at the time of shock is an important factor that determines the shock outcome. Methods: Isolated, perfused rabbit hearts (n = 7) were optically mapped with a potentiometric dye (di-4-ANNEPS). Shocks were delivered during short (10 seconds) and long (1 minute) VF, and the outcome was classified as successful type A (immediate termination), type B (postshock repetitive responses before termination), and unsuccessful. Results: When shock strengths of 50% probability of successful defibrillation (DFT50) ± 50 V were given in short VF, the types A and B and unsuccessful shocks were associated with a preshock PS number of 0.3 ± 0.4, 1.4 ± 0.3, and 1.5 ± 0.4 (P 50, the preshock PS number was still significantly different for short VF (0.6 ± 0.5, 1.6 ± 0.9, and 1.5 ± 0.8; P

Original languageEnglish (US)
Pages (from-to)927-934
Number of pages8
JournalHeart Rhythm
Volume4
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

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Ventricular Fibrillation
Shock
Coloring Agents
Rabbits

Keywords

  • Mapping
  • Sudden cardiac death
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Preshock phase singularity and the outcome of ventricular defibrillation. / Hayashi, Hideki; Lin, Shien-Fong; Chen, Peng-Sheng.

In: Heart Rhythm, Vol. 4, No. 7, 07.2007, p. 927-934.

Research output: Contribution to journalArticle

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AU - Lin, Shien-Fong

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