Pressure-volume and length-stress relationships in canine bronchi in vitro

Susan Gunst, J. Q. Stropp

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Intraparenchymal canine airway segments with branches tied off were mounted between two fluid-filled cannulas in an organ chamber. Airways were inflated to successive volumes ranging from 4 to 100% of the segment volume at 25 cmH2O. At each volume, pressure was monitored during isovolumetric contractions elicited by 10-3 M acetylcholine. Small bronchi developed pressures > 30 cmH2O in response to acetylcholine at all volumes and were able to constrict to closure. Large bronchi developed pressures > 30 cmH2O only near maximal volumes and were able to constrict to only 30% of maximal volume. Maximal active pressures occurred at low volumes in small bronchi and at high volumes in large bronchi. However, maximal active circumferential tension and stress occurred at near-maximal volumes in both large and small bronchi. Circumferential length active-stress curves and maximal active-stress development for bronchi and trachealis muscle strips were similar. Similar length active-stress properties in different bronchi may produce significant differences in volume-pressure characteristics.

Original languageEnglish (US)
Pages (from-to)2522-2531
Number of pages10
JournalJournal of Applied Physiology
Volume64
Issue number6
StatePublished - 1988
Externally publishedYes

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Bronchi
Canidae
Pressure
Acetylcholine
In Vitro Techniques
Muscles

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Pressure-volume and length-stress relationships in canine bronchi in vitro. / Gunst, Susan; Stropp, J. Q.

In: Journal of Applied Physiology, Vol. 64, No. 6, 1988, p. 2522-2531.

Research output: Contribution to journalArticle

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